2013
Susanne Elizabeth Ahmari, M.D., Ph.D.
Columbia University
Testing the Role of Cortico-Striatal Circuits in Obsessive Compulsive Disorder Pathology and Treatment
Gautam Bhave, M.D., Ph.D.
Vanderbilt University Medical Center
Role of Peroxidasin and Protein Halogenation in Diabetic Nephropathy
Ajai Arvind Dandekar, M.D., Ph.D.
University of Washington
Quorum sensing and mechanisms to ensure cooperation in the opportunistic pathogen Pseudomonas aeruginosa
Andrew Eugene Hermann Elia, M.D., Ph.D.
Harvard Medical School
Proteomic analysis of ubiquitination and protein stability in the DNA damage response
Gaorav P Gupta, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
DNA Damage Responses in Breast Cancer Pathogenesis
Andrew Caleb Hsieh, M.D.
University of California-San Francisco
Elucidating the role of aberrant translational control on prostate cancer invasion and metastasis
Jean-Sebastien Joyal, M.D., Ph.D.
University of Montreal Faculty of Medicine
Neuronal Energy Metabolism Drives Angiogenesis
Alex Kentsis, M.D., Ph.D.
Harvard Medical School
Tumorigenesis by endogenous DNA transposons in human cancer.
Jeniel Emily Nett, M.D., Ph.D.
University of Wisconsin-Madison
Mechanisms of Candida Biofilm Immune Evasion
Rhea Myers Sumpter, Jr., M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
A novel role for FANCC in selective autophagy
2012
Chetan Bettegowda, M.D., Ph.D.
Johns Hopkins University
Translational molecular profiling of oligodendrogliomas
Scott Richard Floyd, M.D., Ph.D.
Massachusetts Institute of Technology
Insulating chromatin from DNA damage signaling: epigenetic modifications and connections to human cancer
Benjamin Elison Gewurz, M.D., Ph.D.
Harvard Medical School
Identification of novel NFkB pathway components important for lymphomagenesis
Michael Rosenblum, M.D., Ph.D.
University of California-San Francisco
Memory regulatory T cells in inflammatory and autoimmune disease
Michael Thomas Spiotto, M.D., Ph.D.
University of Chicago
Identification of chromosomal aberrations that cooperate with the human papillomavirus to cause cancer
David Tsai Ting, M.D.
Harvard Medical School
Characterization of non-coding RNAs in pancreatic adenocarcinoma
Richard Chih-Chien Wang, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Akt-mediated regulation of autophagy & tumorigenesis through formation of a beclin 1/keratin intermediate filament complex
Kelley Yan, M.D., Ph.D.
Stanford University
Regulation of active and quiescent intestinal stem cells
Ellen Yeh, M.D., Ph.D.
Stanford University
Function of the plastid organelle in P. falciparum: beyond isoprenoid precursor biosynthesis and blood stage
Hao Zhu, M.D.
Harvard University
Investigating the Lin28/let-7 pathway in mouse models of liver cancer and regeneration
2011
Karin Elisabeth Finberg, M.D., Ph.D.
Duke University School of Medicine
Identification of Novel Genetic Regulators of Mammalian Iron Homeostasis
Karunesh Ganguly, M.D., Ph.D.
University of California-San Francisco
Control of a Complex Neuroprosthetic Device using Electrocorticography
Douglas Sun Kwon, M.D., Ph.D.
Harvard Medical School
New technologies for the study of HIV mucosal immunity and compartmentalization in the female genital tract
Nikhil Vilas Munshi, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Genomic Approaches to Understanding the Cis-Regulatory Architecture of the Atrioventricular Node
Stacey Lynn Rentschler, M.D., Ph.D.
University of Pennsylvania
Role of notch signaling in preexcitation and arrhythmias
Joshua Marc Shulman, M.D., Ph.D.
Harvard Medical School
Exploring the Genetics of Parkinson's Disease in Humans and Drosophila
Eric Lee Snyder, M.D., Ph.D.
Massachusetts Institute of Technology
Regulation of lung cancer progression by the cell fate determinant Nkx2.1
Christopher Ryan Vakoc, M.D., Ph.D.
Cold Spring Harbor Laboratory
Identifying epigenetic vulnerabilities in chemotherapy-resistant leukemia
Kevin Chun-Kai Wang, M.D., Ph.D.
Stanford University
Mechanisms of transcriptional regulation by long noncoding RNAs in partnership with chromatin modifying complexes
Duane Robert Wesemann, M.D., Ph.D.
Harvard Medical School
Extramedullary B Cell Development in the Gut Lamina Propria
2009
Chester Drum, M.D., Ph.D.
Massachusetts Institute of Technology
Protein nanoparticles for small molecule drug delivery
Pradipta Ghosh, M.D.
University of California-San Diego
Modulation of G-protein activity during oncogenic and metastatic progression
Matthew Vander Heiden, M.D., Ph.D.
Harvard Medical School
Metabolic control of cancer cell proliferation by pyruvate kinase M2
Quyen T. Nguyen, M.D., Ph.D.
University of California-San Diego
Testing surgery guided by molecular fluorescence imaging
Ann Zovein, M.D.
University of California-Los Angeles
Hemogenic endothelium: hematopoietic stem cell emergence from the vasculature
2008
Antonios O. Aliprantis, M.D., Ph.D.
Harvard School of Public Health
Novel regulators of the osteoclast differentiation program
Kathleen H. Burns, M.D., Ph.D.
Johns Hopkins University
Role of retrotransposons in hematopoietic neoplasias
Daniel Cahill, M.D., Ph.D.
Harvard School of Public Health
Translational molecular genetic analyses of chemotherapeutic resistance in human brain tumors
Alice Siau-In Chen-Plotkin, M.D.
University of Pennsylvania
Genomic approaches to frontotemporal dementia
Sandeep Robert Datta, M.D., Ph.D.
Columbia University
Characterization of neural circuits that drive innate behaviors
Joseph Alexander Duncan, M.D., Ph.D.
University of North Carolina-Chapel Hill
Dissecting cryopyrin-mediated inflammatory signaling and its role in the pathogenesis of infectious diseases
Wendy Sarah Garrett, M.D., Ph.D.
Harvard School of Public Health
Novel effectors and regulators of inflammation, chronic infection, and carcinogenesis in the colon
Jeffrey Parker Henderson, M.D., Ph.D.
Washington University
Iron acquisition by bacterial siderophores as a pathogenic determinant in urinary track infections
Lu Quang Le, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Cell of origin and tumor microenvironment in NF1-associated neurofibroma development
Ravindra Majeti, M.D., Ph.D.
Stanford University
Identification and targeting of human acute myeloid leukemia stem cell-specific cell surface molecules
Heather Christy Mefford, M.D., Ph.D.
University of Washington
Novel genomic rearrangements in developmental pediatric disorders
Ken Nakamura, M.D., Ph.D.
University of California-San Francisco
Physiologic and pathologic interactions of alpha-synuclein with mitochondria in Parkinson's disease
Robert M. Plenge, M.D., Ph.D.
Harvard Medical School
Genotype-phenotype studies of rheumatoid arthritis susceptibility genes
David Tevis Pride, M.D., Ph.D.
Stanford University
Bacteriophage communities in oral health and disease
Miguel Nicolas Rivera, M.D.
Harvard Medical School
Characterization of a novel X-linked tumor suppressor, WTX, in pediatric cancer
Agata Smogorzewska, M.D., Ph.D.
Harvard Medical School
Role of the Fanconi Anemia and other DNA crosslink repair pathways in genome maintenance and cancer prevention
2007
Jonathan Paul Alexander, M.D., Ph.D.
University of California-San Francisco
Isolation of a putative alveolar stem cell population and analysis of its role in development, maintenance, and repair of the lung epithelium
Robert Baloh, M.D., Ph.D.
Washington University
Mechanism of peripheral neuropathy from Mitofusin 2 mutations
James Elliott Bradner, M.D.
Harvard University
Design and characterization of highly potent inhibitors of HDAC6
Clark C. Chen, M.D., Ph.D.
Harvard Medical School
The molecular basis and therapeutic implications of genome instability during brain tumor progression
Arlene Dent, M.D., Ph.D.
Case Western Reserve University
Acquisition of immunity to blood stage Falciparum malaria in infants
Mahalia Sabrina Desruisseaux, M.D.
Albert Einstein College of Medicine of Yeshiva University
Neuroparasitology: neurological complications of cerebral malaria
Jay F. Dorsey, M.D., Ph.D.
University of Pennsylvania
Identification of mSin3b and Mad4 as novel p53 target genes directing p53-mediated transcriptional repression
Benjamin Levine Ebert, M.D., Ph.D.
Harvard Medical School
Genomic approaches to disorders of erythroid differentiation
Brian Todd Edelson, M.D., Ph.D.
Washington University
Macrophage and dendritic cell development
Rene L. Galindo, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Genetic dissection of the Rhabdomyosarcoma initiator PAX-FKHR and PAX-related signaling in skeletal muscle development
Darnell Kaigler, D.D.S., Ph.D.
University of Michigan-Ann Arbor
Cell therapy for the treatment of alveolar bone defects
Michael Z. Lin, M.D., Ph.D.
University of California-San Diego
Elucidating mechanisms of synaptic plasticity and learning by visualizing and controlling local protein turnover
Roger Lo, M.D., Ph.D.
University of California-Los Angeles
Melanoma in the skin: initiation, progression, and crosstalk with dermal fibroblasts
Emanual Maverakis, M.D.
University of California-Davis
gC399tr an inhibitor of autoimmunity
Eric Matthew Morrow, M.D., Ph.D.
Harvard Medical School
Identification of autism genes in special founder populations using high-density SNP microarrays
Christopher Newton-Cheh, M.D.
Harvard Medical School
Genomic dissection of QT interval duration and sudden death
Dao Nguyen, M.D.
University of Washington
Stringent response in Pseudomonas aeruginosa biofilm formation and antibiotic tolerance
Anil Potti, M.D.
Duke University
Gene expression patterns coupled with signatures of oncogenic pathway deregulation provide a novel approach to targeted therapeutics in non-small cell lung carcinoma
Frank J. Probst, M.D., Ph.D.
Baylor College of Medicine
Generation of mouse models for X-linked diseases
Joseph C. Wu, M.D., Ph.D.
Stanford University
Molecular and cellular mechanisms of cardiac regeneration
Mark Nan Wu, M.D., Ph.D.
University of Pennsylvania
Identification of novel genes that regulate sleep in Drosophila melanogaster