Investigators in the Pathogenesis of Infectious Disease

Grant Recipients

2014
2013
2012
2011
2009
2008
2007
2006
2005
2003
2002

2014

Robert A. Cramer, Ph.D.
Dartmouth College
Bioenergetics and microbial pathogenesis sufficiency

Michael A.  Fischbach, Ph.D.
University of California-San Francisco
Novel microbiota-derived molecules that modulate the host immune response

De'Broski R. Herbert, Ph.D.
University of California-San Francisco
Trefoil factor proteins modulate host immunity against hookworms

Tobias M. Hohl, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
Tracing innate control over respiratory and systemic fungal infection

Alexei V. Korennykh, Ph.D.
Princeton University
Systems analysis of pathogen defense mediated by 2', 5'-linked isoRNA

Matthias Marti, Ph.D.
Harvard University
Cellular communication in malaria parasites

Erika L Pearce, D.Phil., Ph.D.
Washington University
Cellular metabolism in immunity to infection

Manuela Raffatellu, M.D.
University of California-Irvine
Characterization of novel populations of neutrophils during bacterial infection

Daniel B. Stetson, Ph.D.
University of Washington
Why do DNA viruses cause cancer?

Niraj H. Tolia, Ph.D.
Washington University School of Medicine
Molecular basis for and inhibition of red blood cell invasion by Plasmodium parasites

Victor J. Torres, Ph.D.
New York University School of Medicine
Staphylococcus aureus pore-forming toxins: leukocyte killing and beyond

Robert T.  Wheeler, Ph.D.
University of Maine
Phagocytes block fungal dimorphism to defend the epithelial barrier

2013

Abraham Brass, M.D., Ph.D.
University of Massachusetts Medical School
Defining dengue virus’s dependencies: discovery and characterization of host factors required for viral replication

Dustin Brisson, Ph.D.
University of Pennsylvania
Evolution of original antigenic sin in lyme disease

Michael Federle, Ph.D.
University of Illinois-Chicago
Interspecies communication among commensal and pathogenic bacteria

Xiarong Lin, Ph.D.
Texas A&M University
Fungal communication and pathogenicity

Suzanne Noble, M.D., Ph.D.
University of California-San Francisco
Discovery of a cell type switch that drives fungal-mammalian commensalism

Sara Sawyer, Ph.D.
University of Texas-Austin
Genetics of viral species tropism

Emily Troemel, Ph.D.
University of California-San Diego
Microsporidia virulence factors exploit host cell physiology

David Weiss, Ph.D.
Emory University
Novel RNAi-like system controls bacterial innate immune evasion and virulence

Felix Yarovinsky, M.D.
University of Texas Southwestern Medical Center
TLR-independent host resistance to protozoan parasites

Liang Zhou, M.D., Ph.D.
Northwestern University
Environmental impact on host-pathogen interaction

2012

Neal M. Alto, Ph.D.
University of Texas Southwestern Medical Center
Systems architecture of bacterial effector/host membrane interactions

Anna I. Bakardjiev, M.D.
University of California-San Francisco School of Medicine
Pregnancy-related pathogenicity determinants of Listeria monocytogenes

Juliane Bubeck Wardenburg, M.D., Ph.D.
University of Chicago
Tuning of the host-bacterial interaction by a pore-forming toxin

Carolyn B. Coyne, Ph.D.
University of Pittsburgh School of Medicine
Actin cytoskeleton and antiviral innate immune signaling

Sarah M. Fortune, M.D.
Harvard University
Quick change: polarity, diversity and virulence in Mycobacterium tuberculosis

Chyi-Song Hsieh, M.D., Ph.D.
Washington University School of Medicine
Host discrimination between pathogenic and commensal bacteria in the colon

Jonathan C. Kagan, Ph.D.
Harvard Medical School
Novel approaches to study RIG-I like receptor mediated antiviral immunity

Julie K. Pfeiffer, Ph.D.
University of Texas Southwestern Medical Center
How gut microbes enhance enteric virus infectivity

Christopher S. Sullivan, Ph.D.
University of Texas-Austin
Herpes virus immune evasion via non-coding RNA regulatory elements

Sing Sing Way, M.D., Ph.D.
University of Minnesota Medical School
Maternal regulatory T cells control the immune pathogenesis of prenatal infection

2011

David M. Aronoff, M.D.
University of Michigan-Ann Arbor
Prostaglandin E2 synthesis and signaling in the pathogenesis of puerperal Group A Streptococcus infections

Gregory M.  Barton, Ph.D.
University of California-Berkeley
Interactions between TLRs and intracellular pathogens

Julie Magarian Blander, Ph.D.
Mount Sinai School of Medicine
Innate immune recognition of vita-PAMPs: a new class of pathogen associated molecular patterns that signifies microbial viability

Sara R. Cherry, Ph.D.
University of Pennsylvania
Systems biology of Alphavirus infection

Jonathan Dworkin, Ph.D.
Columbia University
Characterization of a novel family of receptors mediating metazoan recognition of microbes

Ekaterina Heldwein, Ph.D.
Tufts University School of Medicine
Structural mechanism of herpes virus egress

Sarkis K. Mazmanian, Ph.D.
California Institute of Technology
Novel probiotic therapy for microbial infections

Joseph D. Mougous, Ph.D.
University of Washington
Breaching the commensal barrier to infection with type VI secretion

Justin L. Sonnenburg, Ph.D.
Stanford University School of Medicine
Mechanisms of intestinal microbiota-conferred protection from enteric pathogens

Benjamin R. tenOever, Ph.D.
Mount Sinai School of Medicine
Small RNA-mediated control of microbes

2009

Jen-Tsan Ashley Chi, M.D., Ph.D.
Duke University Medical Center
Sequence determinant of the Plasmodium falciparum gene regulation by human microRNAs   

K. Heran Darwin, Ph.D.
New York University School of Medicine
Ubiquitin-like proteins in bacterial pathogens

Denise Monack, Ph.D.
Stanford University
Host-pathogen interactions during persistent Salmonella infection   

Maya Saleh, Ph.D.
McGill University
Regulation and molecular mechanisms of NLR-mediated innate immunity

Erica O. Saphire, Ph.D.
Scripps Research Institute
Arenavirus GP:  architecture, receptor binding sites, and immune recognition   

Russell Vance, Ph.D.
University of California-Berkeley
Innate immune cytosolic immunosurveillance pathways for sensing bacterial pathogens

2008

David Artis, Ph.D.
University of Pennsylvania
Tracking helminth-specific immune responses in vivo

Richard Bennett, Ph.D.
Brown University
Phenotypic variation and host adaptation by the human fungal pathogen Candida albicans

Miriam Braunstein, Ph.D.
University of North Carolina-Chapel Hill
Identification of in vivo-secreted proteins of Mycobacterium tuberculosis with roles in host-pathogen interactions

James Carlyle, Ph.D.
University of Toronto
MHC-independent recognition of infected cells by natural killer cells of the innate immune system

Stephen Girardin, Ph.D.
University of Toronto
The Nod-like receptor Nod9 links mitochondrial dynamics and innate immunity to bacterial pathogens

Chuan He, Ph.D.
University of Chicago
How Staphylococcus aureus senses host immune defenses

Kent L. Hill, Ph.D.
University of California-Los Angeles
Cell-cell communication and social motility in pathogenesis and development of African trypanosomes

D. Borden Lacy, Ph.D.
Vanderbilt University Medical Center
Structural mechanisms of Heliobacter pylori pathogenesis

John MacMicking, Ph.D.
Yale University School of Medicine
Immune control of human phagosomal pathogens by a novel GTPase superfamily
 
Adrie J.C. Steyn, Ph.D.
University of Alabama-Birmingham
Carbon monoxide and Mycobacterium tuberculosis persistence

Timothy L. Tellinghuisen, Ph.D.
The Scripps Research Institute
Subversion of a host kinase and vesicle trafficking components for the production of infectious hepatitis C virus

David Wang, Ph.D.
Washington University School of Medicine
A genomics-based approach to novel viral etiologies of diarrhea

Marvin Whiteley, Ph.D.
University of Texas-Austin
Mechanistic insight into host modulation of bacterial group activities

Dong Yu, Ph.D.
Washington University School of Medicine
Modulation of the DNA damage response by human cytomegalovirus

2007

Benjamin K. Chen, M.D., Ph.D.
Mount Sinai School of Medicine
Dissemination of HIV through virological synapses

Andrew Darwin, Ph.D.
New York University School of Medicine
Mechanisms of Pseudomonas aeruginosa tolerance to secretin-induced stress during host infection

Michael R. Farzan, Ph.D.
Harvard Medical School
Parallel identification of obligate viral receptors

Britt Glaunsinger, Ph.D.
University of California-Berkeley
Global modulation of cellular gene expression by an oncogenic human herpesvirus

Karen J. Guillemin, Ph.D.
University of Oregon
Regulation of gut epithelial cell homeostasis by the microbiota

Lora V. Hooper, Ph.D.
University of Texas Southwestern Medical Center
Innate immune responses to commensal bacteria at gut epithelial surfaces

Eckhard Jankowsky, Ph.D.
Case Western Reserve University
Molecular mechanisms of pathogen identification by the pattern recognition receptors RIG-I and MDA5

Barbara I. Kazmierczak, M.D., Ph.D.
Yale University
The role of injury in Pseudomonas aeruginosa pulmonary infection

Manuel Llinas, Ph.D.
Princeton University
Global analysis of the Plasmodium falciparum metabolome

Harmit S. Malik, Ph.D.
University of Washington
Evolution-based identification and functional study of intracellular host-virus interactions

Dorian B. McGavern, Ph.D.
The Scripps Research Institute
Chemical and molecular approaches to probe viral pathogenesis in real time

Yorgo Modis, Ph.D.
Yale University
Cell entry and innate immune recognition of flaviviruses

Neal Silverman, Ph.D.
University of Massachusetts Medical School
Intracellular bacterial recognition in the Drosophila innate immune response

Raphael H. Valdivia, Ph.D.
Duke University Medical Center
The role of secreted bacterial proteases in chlamydial pathogenesis

Andres Vazquez-Torres, D.V.M., Ph.D.
University of Colorado-Denver and Health Sciences Center-Fitzsimons Campus
Effects of nitrosative stress on bacterial two component regulatory systems in innate host defense

Ning Zheng, Ph.D.
University of Washington
Viral hijacking of host ubiquitin ligase machinery

2006

Choukri Ben Mamoun, Ph.D.
University of Connecticut Health Center
Function and regulation of host and parasite nutrient transporters during malaria infection

Helen E. Blackwell, Ph.D.
University of Wisconsin-Madison
Interception of bacterial quorum sensing with synthetic ligands

Blossom Damania, Ph.D.
University of North Carolina-Chapel Hill
Role of viral signaling proteins in the pathogenesis of Kaposi's sarcoma-associated herpes virus (KSHV)

Manoj T Duraisingh, Ph.D.
Harvard School of Public Health
Epigenetic control of virulence gene expression in Plasmodium falciparum

Peter J. Espenshade, Ph.D.
Johns Hopkins University School of Medicine
Oxygen-sensing and adaptation to host tissue hypoxia in the human fungal pathogen Cryptococcus neoformans

Robert F. Kalejta, Ph.D.
University of Wisconsin-Madison
Cellular and viral determinants of human cytomegalovirus lytic and latent replication cycles

Christian Munz, Ph.D.
Rockefeller University
Regulation of macroautophagy by viral infection

Kim Orth, Ph.D.
University of Texas Southwestern Medical Center
VopL, a Vibrio effector that nucleates actin

Ana Rodriguez, Ph.D.
New York University School of Medicine
The role of hypoxanthine degradation in malaria-induced pathogenesis

Karla Fullner Satchell, Ph.D.
Northwestern University
A mouse model for the role of toxins in cholera pathogenesis

Luis M Schang, D.V.M., Ph.D.
University of Alberta
Silencing and antisilencing in the regulation of viral gene expression

Eric Skaar, Ph.D.
Vanderbilt University Medical Center
In vivo identification of Staphylococcus aureus proteins that defend against host neutrophils

Vanessa Sperandio, Ph.D.
University of Texas Southwestern Medical Center
Interkingdom signaling in bacterial pathogenesis

Billy Tsai, Ph.D.
University of Michigan Medical School
How cholera toxin hijacks cellar machineries to transport across the ER membrane?

2005

Jody L. Baron, M.D., Ph.D.
University of California-San Francisco School of Medicine
Understanding immunopathogenesis of Hepatitis B virus

Matthew S. Bogyo, Ph.D.
Stanford University School of Medicine
Chemical mapping of proteolytic networks involved in Toxoplasma gondii pathogenesis

John H. Brumell, Ph.D.
University of Toronto
Recognition of bacteria in the cytosol of mammalian cells by protein conjugation systems

Tatjana Dragic, Ph.D.
Albert Einstein College of Medicine of Yeshiva University
Entry and intracellular trafficking of Hepatitis C virus

Michael S. Glickman, M.D.
Memorial Sloan-Kettering Cancer Center
Regulated intramembrane proteolysis in controlling Mycobacterium tuberculosis virulence and cell envelope composition

Akiko Iwasaki, Ph.D.
Yale University
Stromal cell contributions in innate and adaptive immune responses to mucosal viral infection

John S. Parker, B.V.M.S., Ph.D.
Cornell University College of Veterinary Medicine
Reovirus-induced apoptosis: the role of the viral outer-capsid protein mu1

Lalita Ramakrishnan, M.D., Ph.D.
University of Washington School of Medicine
Forward genetic screens in the zebrafish to identify host determinants of susceptibility to tuberculosis

Gregory A. Smith, Ph.D.
Northwestern University Feinberg School of Medicine
Coordination of herpes virus assembly and transport in axons of sensory neurons

Linda F. van Dyk, Ph.D.
University of Colorado Health Sciences Center
Analyzing tumor suppressors in the control of virus infection and inflammation

Sean P. Whelan, Ph.D.
Harvard Medical School
Exploration of the interaction of RNA viruses with their host cells

2003

David C. Bloom, Ph.D.
University of Florida College of Medicine
Identification of neuron-specific factors that regulate HSV-1 chromatin structure and transcription during latency

Dana A. Davis, Ph.D.
University of Minnesota-Twin Cities
Control of phenotypic switching and pathogenesis by the Mds3 protein

David A. Fidock, Ph.D.
Albert Einstein College of Medicine of Yeshiva University
Plasmodium falciparum transmembrane proteins and their role in parasite susceptibility to heme-binding antimalarials

Michael J. Gale, Jr. Ph.D.
University of Texas Southwestern Medical Center
Control of hepatitis C virus replication

Andrew S. Neish, M.D.
Emory University School of Medicine
Transgenic analysis of prokaryotic effector proteins in the eukaryote, Drosophila melanogaster

Eric J. Rubin, M.D., Ph.D.
Harvard School of Public Health
Cell signaling by bacterial cytokines in Mycobacterium tuberculosis

Wenqing Xu, Ph.D.
University of Washington School of Medicine
Innate immunity: how do Toll-like receptors recognize microbial pathogens?

Thomas C. Zahrt, Ph.D.
Medical College of Wisconsin
Mycobacterium tuberculosis regulators modulating reactivation

2002

Barbara A. Burleigh, Ph.D.
Harvard School of Public Health
Functional characterization of the role of the host cell fibrogenic response in Trypanosoma cruzi infection

Zhijian J. Chen, Ph.D.
University of Texas Southwestern Medical Center
Roles of TRAF5-regulated IKK activators in innate immunity

Maurizio Del Poeta, M.D.
Medical University of South Carolina-College of Medicine
Roles for inositol phosphoryl ceramide synthase 1 (IPC1) in fungal-host interaction

Heidi Goodrich-Blair, Ph.D.
University of Wisconsin-Madison
Pathogenesis of Xenorhabdus nematophilus in insects: a model for the innate immune response to bacterial pathogens

David B. Haslam, M.D.
Washington University-School of Medicine
Mechanisms of Shiga toxin translocation and intoxication within host cells

Margarethe (Meta) J. Kuehn, Ph.D.
Duke University Medical Center
Toxin trafficking via vesicles

C. Erec Stebbins, Ph.D.
Rockefeller University
Structural studies of bacterial virulence factors

Ren Sun, Ph.D.
University of California-Los Angeles-School of Medicine
Identification of cellular factors that determine the fate of herpes virus infection: latency versus lytic replication

Chloe L. Thio, M.D.
Johns Hopkins University School of Medicine
The identification of human genes associated with hepatitis B virus outcomes