Previous Programs

Grant Recipients

Note:  This list reflects the awardees' original grant institution and links may differ.

2009
2008
2007
2006
2005
2003
2002
2001
2000
1999
1998

2009

Thomas R. Hawn, M.D., Ph.D.
University of Washington
Variation and regulation of innate immunity to Mycobacteria

Robert O. Heuckeroth, M.D., Ph.D.
Washington University
Genetic and non-genetic risk for Hirschsprung disease

Ari Melnick, M.D.
Weill Medical College of Cornell University
Differentiation therapy for B-cell lymphomas

Stephanie Ware, M.D., Ph.D.
University of Cincinnati
Uncovering novel genetic causes and risks in congenital heart disease patients

2008

Mark S. Anderson, M.D., Ph.D.
University of California-San Francisco
Translating AIRE-control of immune tolerance to human autoimmunity

Kathleen L. Collins, M.D., Ph.D.
University of Michigan-Ann Arbor
Viral mechanisms of persistence in HIV infected people

Laurence Cooper, M.D., Ph.D.
University of Texas M.D. Anderson Cancer Center
Tumor-specific alloantigen-anergic donor-derived T-cell therapy after hematopoietic stem-cell transplantation

William M. Grady, M.D.
University of Washington
Fred Hutchinson Cancer Research Center
Novel biomarkers for the prevention and treatment of colon cancer

S. Ananth Karumanchi, M.D.
Harvard Medical School
Soluble endoglin in the pathogenesis and prediction of preeclampsia

Francis Lee, M.D., Ph.D.
Weill Medical College of Cornell University
Role of BDNF in therapeutic strategies for affective disorders

Ernst R. Lengyel, M.D., Ph.D.
University of Chicago
Development of novel therapeutic and diagnostic strategies for ovarian cancer

Daniel L. Marks, M.D., Ph.D.
Oregon Health and Science University
Maternal nutrition and fetal metabolic programming

Jonathan R. Pollack, M.D., Ph.D.
Stanford University
Pathogenesis and diagnosis of clinically-indolent prostate cancer

Theodora S. Ross, M.D., Ph.D.
University of Michigan-Ann Arbor
Abnormal HIP1 and cancer biology

Jeffrey A. Toretsky, M.D.
Georgetown University
Novel cancer therapeutics based upon oncogenic fusion-protein transcription factors

Edus H. Warren, M.D., Ph.D.
University of Washington
Fred Hutchinson Cancer Research Center
Toward immune therapy for colon cancer: identification of antigens recognized by CD8 + T lymphocytes on colon cancer stem cells

Kang Zhang, M.D., Ph.D.
University of Utah
Define novel genes for diabetic microvascular complications

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2007

Jayakrishna Ambati, M.D.
University of Kentucky
Suppression of angiogenesis

Kenneth Cusi, M.D.
University of Texas-San Antonio Health Science Center
Non-alcoholic fatty liver disease in type 2 diabetes: a novel intervention strategy targeting metabolic & molecular defects

Michael R. DeBaun, M.D.
Washington University
Cysteinyl leukotriene receptor inhibitors: a target for decreasing sickle cell disease-related morbidity

Michael S. Diamond, M.D., Ph.D.
Washington University
Epitope-based immunogens and diagnostics for dengue virus

Anna Huttenlocher, M.D.
University of Wisconsin-Madison
Diagnosis and treatment of autoinflammatory disease

Branch Moody, M.D.
Harvard Medical School
Human T-cell responses to CD1 and lipid antigens from M. tuberculosis

Annabelle Rodriguez, M.D.
Johns Hopkins University School of Medicine
Deficiency of the lipoprotein receptor, scavenger receptor class B type I, in women with infertility

Norman E. Sharpless, M.D.
University of North Carolina-Chapel Hill
The p16INK4 a tumor suppressor in stem cell aging

Warren D. Shlomchik, M.D.
Yale University
Memory T cells for improved immune reconstitution and GVL in allogeneic hematopoietic stem cell transplantation

Pradeep Singh, M.D.
University of Washington
Gallium as an antimicrobial and anti-biofilm agent: a trojan horse strategy that disrupts bacterial iron metabolism

Russell Van Gelder, M.D., Ph.D.
Washington University
Pathogenesis of inflammatory eye disease

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2006

Richard J. Auchus, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Pharmacogenomics of hypertension

Arul M. Chinnaiyan, M.D., Ph.D.
University of Michigan-Ann Arbor
Autoantibody profiles for cancer diagnosis, prognosis, and therapy

Bruce E. Clurman, M.D., Ph.D.
University of Washington
Fred Hutchinson Cancer Research Center
Diagnostic and therapeutic approaches to cell cycle-associated cancer

Dean Y. Li, M.D., Ph.D.
University of Utah
Therapeutic potential of vascular guidance cues

Ali J. Marian, M.D.
Baylor College of Medicine
Molecular genetics and pathogenesis of human arrhythmogenic right ventricular cardiomyopathy/dysplasia

Kerry J. Ressler, M.D., Ph.D.
Emory University
Neurobiology of fear, neuroplasticity and posttraumatic stress disorder

Charles M. Rudin, M.D., Ph.D.
Johns Hopkins University
Novel therapeutic strategies for small cell lung cancer

Jean E. Schaffer, M.D.
Washington University
Lipotoxic cardiomyopathy: from molecular mechanisms to human disease

William Weiss, M.D., Ph.D.
University of California-San Francisco
Combination therapy against EGFR and PI3-kinase in glioma

Cassian Yee, M.D.
University of Washington
Fred Hutchinson Cancer Research Center
Adoptive therapy of cancer: strategies to augment the antigen-specific T cell response

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2005

Andrew D. Badley, M.D., F.R.C.P.
Mayo Clinic Rochester
Novel antiapoptotic therapies for sepsis

Kenneth R. Cooke, M.D.
University of Michigan Medical School
Acute lung injury after SCT: from laboratory insights to novel strategies for diagnosis and treatment

James E. Crowe, Jr., M.D.
Vanderbilt University School of Medicine
Immunology and cell biology of human metapneumovirus infections

Dean W. Felsher, M.D., Ph.D.
Stanford University School of Medicine
Pre-clinical validation of g-quadruplex drugs that target MYC to treat cancer

Joseph G. Gleeson, M.D.
University of California-San Diego School of Medicine
Causes and pathogenesis of cerebellar malformation syndromes in humans: bedside to bench

Jeffrey S. Glenn, M.D., Ph.D.
Stanford University School of Medicine
Hepatitis C virus: from molecular virology to effective pharmacologic eradication

Richard J. O’Brien, M.D., Ph.D.
Johns Hopkins University School of Medicine
Alzheimers disease and synaptic transmission

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2003

George Q. Daley, M.D., Ph.D.
Children's Hospital Boston
Harvard Medical School
Chemotherapy and stem cell transplantation in leukemia

Jane E. Koehler, M.D.
University of California-San Francisco School of Medicine
Genomic and clinical correlates of human Bartonella quintana infection

David M. Markovitz, M.D.
University of Michigan-Ann Arbor
New approaches to inhibiting HIV replication

Sofia D. Merajver, M.D., Ph.D.
University of Michigan-Ann Arbor
Genetic determinants of aggressive breast cancer phenotypes: translation to the clinic

Cam Patterson, M.D.
University of North Carolina-Chapel Hill School of Medicine
Oxidative profiles in cardiovascular diseases

Donald Small, M.D., Ph.D.
Johns Hopkins School of Medicine
Translating FLT3 inhibition into improved therapy for pediatric AML and infant ALL

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2002

David M. Altshuler, M.D., Ph.D.
Massachusetts General Hospital
Genomic approaches to the genetics of type 2 diabetes and response to antidiabetic medication

Judy H. Cho, M.D.
University of Chicago Pritzker School of Medicine
Characterization of expression patterns in monocyte-derived cells in inflammatory bowel disease

Barry A. Finette, M.D., Ph.D.
University of Vermont College of Medicine
Mechanisms of malignant transformation in humans

Thomas J.Hudson, M.D.
McGill University Faculty of Medicine
Genomic approaches to identify genes predisposing to asthma

Jonathan D. Licht, M.D.
Mt. Sinai School of Medicine
Targeting aberrant repression as a therapeutic strategy in hematological malignancy

Hector D. Molina, M.D.
Washington University School of Medicine
Mechanisms of complement-induced abnormalities in fetomaternal tolerance

David T. Scadden, M.D.
Massachusetts General Hospital
Developing control mechanism-based stem cell therapies

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2001

Sunil K. Ahuja, M.D.
University of Texas Health Science Center-San Antonio
HIV-1 AIDS pathogenesis: bridging the gap between host genotype and HIV transmission/disease phenotype

Cameron S. Carter, M.D.
University of Pittsburgh School of Medicine
Multimodal brain imaging and the pharmacotherapy of cognitive disability in schizophrenia

Jeffrey A. Drebin, M.D., Ph.D.
Washington University School of Medicine
Targeted suppression of beta-catenin in colorectal cancer

Glenn I. Fishman, M.D.
Mount Sinai School of Medicine
Gap junction channels as novel anti-arrhythmic targets

Lisa M. Guay-Woodford, M.D.
University of Alabama-Birmingham School of Medicine
Genetic modifiers in recessive polycystic kidney disease: implications for pathogenesis and therapeutics

Marshall S. Horwitz, M.D., Ph.D.
University of Washington School of Medicine
Therapeutic inhibition of aberrant protease activity in inherited neutropenias

Elizabeth M. McNally, M.D., Ph.D.
University of Chicago
Microvascular spasm in the progression of cardiomyopathy

Anthony J. Muslin, M.D.
Washington University School of Medicine
Signaling mechanisms in cardiovascular disease

Steven A. Porcelli, M.D.
Albert Einstein College of Medicine
Defining the protective human CD8+ T-cell response against Mycobacterium tuberculosis

Marc E. Rothenberg, M.D., Ph.D.
University of Cincinnati College of Medicine
Experimental analysis of eosinophil-associated gastrointestinal inflammation

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2000

Robert B. Darnell, M.D., Ph.D.
Rockefeller University
Detection and activation of tumor-specific killer cells in animal models and cancer patients

Brian J. Druker, M.D.
Oregon Health Sciences University
Mechanism-based therapy for chronic myelogenous leukemia

Thomas F. Gajewski, M.D., Ph.D.
University of Chicago Pritzker School of Medicine
Development of a second generation melanoma vaccine

Daniel C. Javitt, M.D., Ph.D.
New York University School of Medicine
NMDA-based treatment development for schizophrenia

Joseph M. McCune, M.D., Ph.D.
University of California-San Francisco School of Medicine
Gladstone Institute of Virology and Immunology
Regulation of human thymic function in vivo

M. Juliana McElrath, M.D., Ph.D.
University of Washington School of Medicine
Fred Hutchinson Cancer Research Center
Induction of cellular immunity in HIV-1 exposed seronegative individuals

Mark R. Philips, M.D.
New York University School of Medicine
Endomembrane trafficking of Ras: novel molecular targets for anticancer agents

Daniel J. Rader, M.D.
University of Pennsylvania School of Medicine
Novel therapeutic approach to atherosclerosis through modulation of HDL metabolism

Don C. Rockey, M.D.
Duke University Medical Center
The cellular and molecular basis of portal hypertension: an endothelialopathy in cirrhosis

Matthew L.Warman, M.D.
Case Western Reserve University School of Medicine
Delineating the proteins and pathways that maintain human joints and their potential for treating heritable and acquired forms of arthritis

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1999

Nina Bhardwaj, M.D., Ph.D.
Rockefeller University
Vaccination of HIV-1 positive individuals by antigen-pulsed dendritic cells

Eva Guinan, M.D.
Harvard Medical School
Dana Farber Cancer Institute
Extending the donor pool by inducing alloantigen specific T-cell anergy ex vivo for human hematopoietic stem cell transplantation

Barbara Hempstead, M.D., Ph.D.
Weill Medical College of Cornell University
Growth factor regulation of coronary angiogenesis

Jason M. Morrow, M.D.
Vanderbilt University School of Medicine
Isoprostanes as markers and mediators of oxidant stress in humans

W. Edward Robinson Jr., M.D., Ph.D.
University of California-Irvine College of Medicine
Structure-function analyses of clinically relevant HIV integrases

Antony Rosen, M.B., Ch.B.
Johns Hopkins University School of Medicine
Altered structure and clearance of autoantigens during apoptosis: implications for autoimmunity

Ann Marie Schmidt, M.D.
Columbia University College of Physicians and Surgeons
Novel therapeutic strategy for the prevention and treatment of diabetic complications: antagonism of receptor for advanced glycation end products

Mark H. Siegelman, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Functionally activated lymphocyte CD44 in the initiation and perpetuation of autoimmune disease

Dennis J. Templeton, M.D., Ph.D.
Case Western Reserve University School of Medicine
Stress signaling inhibitors potentiate genotoxin-induced apoptosis in a human colon tumor model

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1998

Gilbert Chu, M.D., Ph.D.
Stanford University Medical Center
Cancer treatment by genome-wide transcription scanning

Claire M. Doerschuk, M.D.
Case Western Reserve University School of Medicine
The response of neutrophils during inflammatory lung disease

Robert W.Doms, M.D., Ph.D.
University of Pennsylvania School of Medicine
Chemokine receptors as new targets for HIV-1 therapeutics

Erol Fikrig, M.D.
Yale University School of Medicine
Borrelia gene expression and lyme arthritis

Alex E. MacKenzie, M.D., Ph.D.
University of Ottawa Faculty of Medicine
The cytoprotective NAIP and XIAP genes: identification of activation pathways and inducing agents

Howard A. Rockman, M.D.
Duke University Medical Center
Novel molecular therapeutic strategies in heart failure: role of beta-adrenergic receptor desensitization

Christian W. Schindler, M.D., Ph.D.
Columbia University College of Physicians and Surgeons
Intervention of IL-5 signaling: a therapeutic paradigm for asthma

Joyce M. Slingerland, M.D., Ph.D.
University of Miami School of Medicine
Resistance to tamoxifen: a consequence of altered p27Kip1 regulation during breast cancer progression

Mark J. Yeager, M.D., Ph.D.
Scripps Research Institute
Structure and function of cardiac gap junction membrane channels

Hagop Youssoufian, M.D.
Baylor College of Medicine
Transcellular gene therapy: application to Fanconi anemia

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