Note: This list reflects the awardees' original grant institution and links may differ.
2009
2008
2007
2006
2005
2003
2002
2001
2000
1999
1998
2009
Thomas R. Hawn, M.D., Ph.D.
University of Washington
Variation and regulation of innate immunity to Mycobacteria
Robert O. Heuckeroth, M.D., Ph.D.
Washington University
Genetic and non-genetic risk for Hirschsprung disease
Ari Melnick, M.D.
Weill Medical College of Cornell University
Differentiation therapy for B-cell lymphomas
Stephanie Ware, M.D., Ph.D.
University of Cincinnati
Uncovering novel genetic causes and risks in congenital heart disease patients
2008
Mark S. Anderson, M.D., Ph.D.
University of California-San Francisco
Translating AIRE-control of immune tolerance to human autoimmunity
Kathleen L. Collins, M.D., Ph.D.
University of Michigan-Ann Arbor
Viral mechanisms of persistence in HIV infected people
Laurence Cooper, M.D., Ph.D.
University of Texas M.D. Anderson Cancer Center
Tumor-specific alloantigen-anergic donor-derived T-cell therapy after hematopoietic stem-cell transplantation
William M. Grady, M.D.
University of Washington
Fred Hutchinson Cancer Research Center
Novel biomarkers for the prevention and treatment of colon cancer
S. Ananth Karumanchi, M.D.
Harvard Medical School
Soluble endoglin in the pathogenesis and prediction of preeclampsia
Francis Lee, M.D., Ph.D.
Weill Medical College of Cornell University
Role of BDNF in therapeutic strategies for affective disorders
Ernst R. Lengyel, M.D., Ph.D.
University of Chicago
Development of novel therapeutic and diagnostic strategies for ovarian cancer
Daniel L. Marks, M.D., Ph.D.
Oregon Health and Science University
Maternal nutrition and fetal metabolic programming
Jonathan R. Pollack, M.D., Ph.D.
Stanford University
Pathogenesis and diagnosis of clinically-indolent prostate cancer
Theodora S. Ross, M.D., Ph.D.
University of Michigan-Ann Arbor
Abnormal HIP1 and cancer biology
Jeffrey A. Toretsky, M.D.
Georgetown University
Novel cancer therapeutics based upon oncogenic fusion-protein transcription factors
Edus H. Warren, M.D., Ph.D.
University of Washington
Fred Hutchinson Cancer Research Center
Toward immune therapy for colon cancer: identification of antigens recognized by CD8 + T lymphocytes on colon cancer stem cells
Kang Zhang, M.D., Ph.D.
University of Utah
Define novel genes for diabetic microvascular complications
2007
Jayakrishna Ambati, M.D.
University of Kentucky
Suppression of angiogenesis
Kenneth Cusi, M.D.
University of Texas-San Antonio Health Science Center
Non-alcoholic fatty liver disease in type 2 diabetes: a novel intervention strategy targeting metabolic & molecular defects
Michael R. DeBaun, M.D.
Washington University
Cysteinyl leukotriene receptor inhibitors: a target for decreasing sickle cell disease-related morbidity
Michael S. Diamond, M.D., Ph.D.
Washington University
Epitope-based immunogens and diagnostics for dengue virus
Anna Huttenlocher, M.D.
University of Wisconsin-Madison
Diagnosis and treatment of autoinflammatory disease
Branch Moody, M.D.
Harvard Medical School
Human T-cell responses to CD1 and lipid antigens from M. tuberculosis
Annabelle Rodriguez, M.D.
Johns Hopkins University School of Medicine
Deficiency of the lipoprotein receptor, scavenger receptor class B type I, in women with infertility
Norman E. Sharpless, M.D.
University of North Carolina-Chapel Hill
The p16INK4 a tumor suppressor in stem cell aging
Warren D. Shlomchik, M.D.
Yale University
Memory T cells for improved immune reconstitution and GVL in allogeneic hematopoietic stem cell transplantation
Pradeep Singh, M.D.
University of Washington
Gallium as an antimicrobial and anti-biofilm agent: a trojan horse strategy that disrupts bacterial iron metabolism
Russell Van Gelder, M.D., Ph.D.
Washington University
Pathogenesis of inflammatory eye disease
2006
Richard J. Auchus, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Pharmacogenomics of hypertension
Arul M. Chinnaiyan, M.D., Ph.D.
University of Michigan-Ann Arbor
Autoantibody profiles for cancer diagnosis, prognosis, and therapy
Bruce E. Clurman, M.D., Ph.D.
University of Washington
Fred Hutchinson Cancer Research Center
Diagnostic and therapeutic approaches to cell cycle-associated cancer
Dean Y. Li, M.D., Ph.D.
University of Utah
Therapeutic potential of vascular guidance cues
Ali J. Marian, M.D.
Baylor College of Medicine
Molecular genetics and pathogenesis of human arrhythmogenic right ventricular cardiomyopathy/dysplasia
Kerry J. Ressler, M.D., Ph.D.
Emory University
Neurobiology of fear, neuroplasticity and posttraumatic stress disorder
Charles M. Rudin, M.D., Ph.D.
Johns Hopkins University
Novel therapeutic strategies for small cell lung cancer
Jean E. Schaffer, M.D.
Washington University
Lipotoxic cardiomyopathy: from molecular mechanisms to human disease
William Weiss, M.D., Ph.D.
University of California-San Francisco
Combination therapy against EGFR and PI3-kinase in glioma
Cassian Yee, M.D.
University of Washington
Fred Hutchinson Cancer Research Center
Adoptive therapy of cancer: strategies to augment the antigen-specific T cell response
2005
Andrew D. Badley, M.D., F.R.C.P.
Mayo Clinic Rochester
Novel antiapoptotic therapies for sepsis
Kenneth R. Cooke, M.D.
University of Michigan Medical School
Acute lung injury after SCT: from laboratory insights to novel strategies for diagnosis and treatment
James E. Crowe, Jr., M.D.
Vanderbilt University School of Medicine
Immunology and cell biology of human metapneumovirus infections
Dean W. Felsher, M.D., Ph.D.
Stanford University School of Medicine
Pre-clinical validation of g-quadruplex drugs that target MYC to treat cancer
Joseph G. Gleeson, M.D.
University of California-San Diego School of Medicine
Causes and pathogenesis of cerebellar malformation syndromes in humans: bedside to bench
Jeffrey S. Glenn, M.D., Ph.D.
Stanford University School of Medicine
Hepatitis C virus: from molecular virology to effective pharmacologic eradication
Richard J. O’Brien, M.D., Ph.D.
Johns Hopkins University School of Medicine
Alzheimers disease and synaptic transmission
2003
George Q. Daley, M.D., Ph.D.
Children's Hospital Boston
Harvard Medical School
Chemotherapy and stem cell transplantation in leukemia
Jane E. Koehler, M.D.
University of California-San Francisco School of Medicine
Genomic and clinical correlates of human Bartonella quintana infection
David M. Markovitz, M.D.
University of Michigan-Ann Arbor
New approaches to inhibiting HIV replication
Sofia D. Merajver, M.D., Ph.D.
University of Michigan-Ann Arbor
Genetic determinants of aggressive breast cancer phenotypes: translation to the clinic
Cam Patterson, M.D.
University of North Carolina-Chapel Hill School of Medicine
Oxidative profiles in cardiovascular diseases
Donald Small, M.D., Ph.D.
Johns Hopkins School of Medicine
Translating FLT3 inhibition into improved therapy for pediatric AML and infant ALL
2002
David M. Altshuler, M.D., Ph.D.
Massachusetts General Hospital
Genomic approaches to the genetics of type 2 diabetes and response to antidiabetic medication
http://www-genome.wi.mit.edu/mpg/
Judy H. Cho, M.D.
University of Chicago Pritzker School of Medicine
Characterization of expression patterns in monocyte-derived cells in inflammatory bowel disease
Barry A. Finette, M.D., Ph.D.
University of Vermont College of Medicine
Mechanisms of malignant transformation in humans
Thomas J.Hudson, M.D.
McGill University Faculty of Medicine
Genomic approaches to identify genes predisposing to asthma
Jonathan D. Licht, M.D.
Mt. Sinai School of Medicine
Targeting aberrant repression as a therapeutic strategy in hematological malignancy
Hector D. Molina, M.D.
Washington University School of Medicine
Mechanisms of complement-induced abnormalities in fetomaternal tolerance
David T. Scadden, M.D.
Massachusetts General Hospital
Developing control mechanism-based stem cell therapies
2001
Sunil K. Ahuja, M.D.
University of Texas Health Science Center-San Antonio
HIV-1 AIDS pathogenesis: bridging the gap between host genotype and HIV transmission/disease phenotype
Cameron S. Carter, M.D.
University of Pittsburgh School of Medicine
Multimodal brain imaging and the pharmacotherapy of cognitive disability in schizophrenia
Jeffrey A. Drebin, M.D., Ph.D.
Washington University School of Medicine
Targeted suppression of beta-catenin in colorectal cancer
Glenn I. Fishman, M.D.
Mount Sinai School of Medicine
Gap junction channels as novel anti-arrhythmic targets
Lisa M. Guay-Woodford, M.D.
University of Alabama-Birmingham School of Medicine
Genetic modifiers in recessive polycystic kidney disease: implications for pathogenesis and therapeutics
Marshall S. Horwitz, M.D., Ph.D.
University of Washington School of Medicine
Therapeutic inhibition of aberrant protease activity in inherited neutropenias
Elizabeth M. McNally, M.D., Ph.D.
University of Chicago
Microvascular spasm in the progression of cardiomyopathy
Anthony J. Muslin, M.D.
Washington University School of Medicine
Signaling mechanisms in cardiovascular disease
Steven A. Porcelli, M.D.
Albert Einstein College of Medicine
Defining the protective human CD8+ T-cell response against Mycobacterium tuberculosis
Marc E. Rothenberg, M.D., Ph.D.
University of Cincinnati College of Medicine
Experimental analysis of eosinophil-associated gastrointestinal inflammation
2000
Robert B. Darnell, M.D., Ph.D.
Rockefeller University
Detection and activation of tumor-specific killer cells in animal models and cancer patients
Brian J. Druker, M.D.
Oregon Health Sciences University
Mechanism-based therapy for chronic myelogenous leukemia
Thomas F. Gajewski, M.D., Ph.D.
University of Chicago Pritzker School of Medicine
Development of a second generation melanoma vaccine
Daniel C. Javitt, M.D.,Ph.D.
New York University School of Medicine
NMDA-based treatment development for schizophrenia
Joseph M. McCune, M.D., Ph.D.
University of California-San Francisco School of Medicine
Gladstone Institute of Virology and Immunology
Regulation of human thymic function in vivo
M. Juliana McElrath, M.D., Ph.D.
University of Washington School of Medicine
Fred Hutchinson Cancer Research Center
Induction of cellular immunity in HIV-1 exposed seronegative individuals
Mark R. Philips, M.D.
New York University School of Medicine
Endomembrane trafficking of Ras: novel molecular targets for anticancer agents
Daniel J. Rader, M.D.
University of Pennsylvania School of Medicine
Novel therapeutic approach to atherosclerosis through modulation of HDL metabolism
Don C. Rockey, M.D.
Duke University Medical Center
The cellular and molecular basis of portal hypertension: an endothelialopathy in cirrhosis
Matthew L.Warman, M.D.
Case Western Reserve University School of Medicine
Delineating the proteins and pathways that maintain human joints and their potential for treating heritable and acquired forms of arthritis
1999
Nina Bhardwaj, M.D., Ph.D.
Rockefeller University
Vaccination of HIV-1 positive individuals by antigen-pulsed dendritic cells
Eva Guinan, M.D.
Harvard Medical School
Dana Farber Cancer Institute
Extending the donor pool by inducing alloantigen specific T-cell anergy ex vivo for human hematopoietic stem cell transplantation
Barbara Hempstead, M.D., Ph.D.
Weill Medical College of Cornell University
Growth factor regulation of coronary angiogenesis
Jason M. Morrow, M.D. (Deceased)
Vanderbilt University School of Medicine
The isoprostanes as markers and mediators of oxidant stress in humans
W. Edward Robinson Jr., M.D., Ph.D.
University of California-Irvine College of Medicine
Structure-function analyses of clinically relevant HIV integrases
Antony Rosen, M.B., Ch.B.
Johns Hopkins University School of Medicine
Altered structure and clearance of autoantigens during apoptosis: implications for autoimmunity
Ann Marie Schmidt, M.D.
Columbia University College of Physicians and Surgeons
Novel therapeutic strategy for the prevention and treatment of diabetic complications: antagonism of receptor for advanced glycation end products
Mark H. Siegelman, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Functionally activated lymphocyte CD44 in the initiation and perpetuation of autoimmune disease
Dennis J. Templeton, M.D., Ph.D.
Case Western Reserve University School of Medicine
Stress signaling inhibitors potentiate genotoxin-induced apoptosis in a human colon tumor model
1998
Gilbert Chu, M.D., Ph.D.
Stanford University Medical Center
Cancer treatment by genome-wide transcription scanning
Claire M. Doerschuk, M.D.
Case Western Reserve University School of Medicine
The response of neutrophils during inflammatory lung disease
Robert W.Doms, M.D., Ph.D.
University of Pennsylvania School of Medicine
Chemokine receptors as new targets for HIV-1 therapeutics
Erol Fikrig, M.D.
Yale University School of Medicine
Borrelia gene expression and lyme arthritis
Alex E. MacKenzie, M.D., Ph.D.
University of Ottawa Faculty of Medicine
The cytoprotective NAIP and XIAP genes: identification of activation pathways and inducing agents
Howard A. Rockman, M.D.
Duke University Medical Center
Novel molecular therapeutic strategies in heart failure: role of beta-adrenergic receptor desensitization
Christian W. Schindler, M.D., Ph.D.
Columbia University College of Physicians and Surgeons
Intervention of IL-5 signaling: a therapeutic paradigm for asthma
Joyce M. Slingerland, M.D., Ph.D.
University of Miami School of Medicine
Resistance to tamoxifen: a consequence of altered p27Kip1 regulation during breast cancer progression
Mark J. Yeager, M.D., Ph.D.
Scripps Research Institute
Structure and function of cardiac gap junction membrane channels
Hagop Youssoufian, M.D.
Baylor College of Medicine
Transcellular gene therapy: application to Fanconi anemia