Scientific advances such as genomics, quantitative structural biology, imaging techniques, and modeling of complex systems have created opportunities for exciting research careers at the interface between the physical/computational sciences and the biological sciences. Tackling key problems in biology will require scientists trained in areas such as chemistry, physics, applied mathematics, computer science, and engineering.

Recognizing the vital role such cross-trained scientists will play in furthering biomedical science, the Burroughs Wellcome Fund has developed the Career Awards at the Scientific Interface. These grants are intended to foster the early career development of researchers who have transitioned or are transitioning from undergraduate and/or graduate work in the physical/mathematical/computational sciences or engineering into postdoctoral work in the biological sciences, and who are dedicated to pursuing a career in academic research.

Candidates are expected to draw from their training in a scientific field other than biology to propose innovative approaches to answer important questions in the biological sciences. Examples of approaches include, but are not limited to, physical measurement of biological phenomena, computer simulation of complex processes in physiological systems, mathematical modeling of self-organizing behavior, building probabilistic tools for medical diagnosis, developing novel imaging tools or biosensors, developing or applying nanotechnology to manipulate cellular systems, predicting cellular responses to topological clues and mechanical forces, and developing a new conceptual understanding of the complexity of living organisms. Proposals that include experimental validation of theoretical models are particularly encouraged.