Investigators in the Pathogenesis of Infectious Disease

Grant Recipients




Theresa Alenghat, DVM., PhD
University of Cincinnati
Dietary regulation of innate intestinal immunity

Francis Alonzo, PhD
Loyola University-Chicago
Deciphering how bacterial pathogens evade innate immunity

Isaac M. Chiu, PhD
Harvard Medical School
Neuronal regulation of influenza virus infection

Jun R. Huh, PhD
Harvard Medical School
Maternal gut bacteria, viral infection and neurodevelopmental disorder

Ivaylo Ivanov, PhD
Columbia University
Regulation of mucosal infections by innate lymphoid cells

Leigh Knodler, PhD
Washington State University
Remain confined or break free? Intracellular niche selection by Gram-negative bacteria

Kristin N. Parent, PhD
Michigan State University
Enter the goliaths: structure and function of giant virus entry mechanisms

John W. Schoggins, PhD
University of Texas Southwestern Medical Center-Dallas
Genetic dissection of innate immune pathways that modulate viral infection

Kimberley D. Seed, PhD
University of California - Berkeley
The impact of fluctuating microenvironments on phage-bacteria interactions in the human intestinal tract

Randy Stockbridge, PhD
University of Michigan-Ann Arbor
The molecular physiology of long-range electrical communication in bacterial biofilms

Ellen Yeh, MD, PhD
Stanford University
Targeting an ancient endosymbiosis in modern-day parasites


Jan E. Carette, Ph.D.
Hunting host factors critical for viral infection

James J. Collins, Ph.D.
University of Texas Southwestern Medical Center-Dallas
Defining regulators of schistosome reproductive development

Jorge Henao-Mejia, M.D., Ph.D.
University of Pennsylvania Perelman School of Medicine
Regulation of white adipose tissue by the microbiota

Ivan Marazzi, Ph.D.
Icahn School of Medicine at Mount Sinai
Role of nuclear granules in viral pathogenesis

John-Demian Sauer, Ph.D.
University of Wisconsin-Madison
The war within: identification and characterization of antibacterial cell instrinsic defenses in the host cell cytosol

Aimee Shen, Ph.D.
Tufts University School of Medicine
Role of a conserved DNA methyltransferase during Clostridium difficile infection

Michael Shiloh, M.D., Ph.D.
University of Texas Southwestern Medical Center-Dallas
Effect of mycobacterial lipid mediators on nociceptive neurons and cough induction

Gregory F. Sonnenberg, Ph.D.
Weill Medical College of Cornell University
Innate immune regulation of host-microbe interaction

Peter J. Turnbaugh, Ph.D.
University of California-San Francisco
Koch's postulates revisited: microbiome editing to prove the microbial etiology of human disease

David Veesler, Ph.D.
University of Washington
Characterization of the mechanisms of Nipah virus entry into host cells and humoral immune response

Gabriel D. Victora, Ph.D.
Rockefeller University
How prior antigenic exposure constrains the response to influenza vaccination

Sebastian E. Winter, Ph.D.
University of Texas Southwestern Medical Center-Dallas
Metabolic host-microbe interactions in the intestinal tract


Catherine Blish, MD, PhD
Stanford University
Training natural killer cells to fight HIV

Caroline Buckee, PhD 
Harvard School of Public Health
The impact of human red blood cell heterogeneities and dynamics on malaria parasite virulence

Jason M. Crawford, PhD 
Yale University
A functional metagenomic screen to systematically identify human-bacteria interactions

Elizabeth A. Grice, PhD 
University of Pennsylvania
Skin microbiome functions in colonization resistance to pathogens

Stacy M. Horner, PhD 
Duke University Medical Center
Regulation of antiviral host response by RNA modifications

Adam S. Lauring, MD, PhD 
University of Michigan-Ann Arbor
The evolution of pathogen virulence and transmissibility

Andrew Mehle, Ph.D. 
University of Wisconsin
Defining the functional landscape between intracellular pathogens and the host

Marion Pepper, PhD 
University of Washington
The development and function of Plasmodium-specific memory B cells

June Round, PhD 
University of Utah
Influence of the microbiota on neuro-inflammation

Mohammad R. Seyedsayamdost, PhD 
Princeton University
Deciphering the small molecule vocabulary of human microbiome Streptococci

Christina Stallings, PhD 
Washington University
Consequences of neutrophil-mycobacteria interactions

Harris Wang, Ph.D.
Columbia University
Mapping host-microbe and inter-microbial networks at ultra-high spatial resolution


Jörn Coers, D.Phil., Ph.D.
Duke University
Host-mediated lysis of cytoplasmic pathogens

Min Dong, Ph.D.
Harvard Medical School
Host factors conferring susceptibility to Clostridium difficile toxins

Christine M. Dunham, Ph.D.
Emory University School of Medicine
Characterization of pathways involved in bacterial persistence and antibiotic resistence

Nels C. Elde, Ph.D.
University of Utah
A new class of retrogenes modulating pathogenesis

Scott E. Hensley, Ph.D.
University of Pennsylvania
Effect of maternal antibodies on the neonatal immune response to influenza virus

Audrey R. Odom, M.D., Ph.D.
Washington University
Insights into the chemical ecology of malaria parasites

Alexander Ploss, Ph.D.
Princeton University
Breaking species barriers of human hepatotropic pathogens

Amariliz Rivera, Ph.D.
Rutgers University-Rutgers Biomedical and Health Sciences-New Jersey Medical School
Mechanisms of bidirectional innate cell licensing in antifungal immunity

Sunny Shin, Ph.D.
University of Pennsylvania Perelman School of Medicine
Overcoming pathogen-mediated translation inhibition to enable robust immune defense

Joseph C. Sun, Ph.D.
Memorial Sloan-Kettering Cancer Center
Natural killer cell control of cytomegalovirus infection


Jesse D. Bloom, Ph.D.
University of Washington
Understanding the stochasticity of viral infection at the level of single cells 

Igor E. Brodsky, Ph.D.
University of Pennsylvania
The role of chemokine-chemokine receptor interactions in anti-bacterial protective immunity

Ken Cadwell, Ph.D.
New York University School of Medicine
Gene-microbe interactions in inflammatory bowel disease

Matthew James Evans, Ph.D.
Icahn School of Medicine at Mount Sinai
Determinants of hepatitis C virus persistence

Andrew L. Goodman, Ph.D.
Yale University
Understanding pathogen-commensal interaction in the earliest stages of infection

Elissa A. Hallem, Ph.D.
University of California-Los Angeles
Deciphering the interactions between skin-penetrating nematodes and bacteria

Sun Hur, Ph.D.
Harvard Medical School
Mechanism for dsRNA-dependent and -independent activation of the antiviral gene, PKR

Rahul Manu Kohli, M.D., Ph.D.
University of Pennsylvania
Tuning evolution and antibiotic resistance by modulating the SOS pathway

Li-Jun Ma, Ph.D.
University of Massachusetts-Amherst 
Supernumerary chromosomes and pathogenicity of opportunistic fungal infections

Luciano A. Marraffini, Ph.D.
Rockefeller University
Effect of type III CRISPR-Cas immunity on phage-mediated staphylococcal pathogenesis

Daniel Mucida, Ph.D.
Rockefeller University
Adaptation of immune cells to the gut tissue: consequences for immunity and tolerance

Nan Yan, D.Phil.
University of Texas Southwestern Medical Center-Dallas
Innate immune sensing and pathogenesis of cytosolic bacteria


Robert A. Cramer, Ph.D.
Dartmouth College
Bioenergetics and microbial pathogenesis sufficiency

Michael A.  Fischbach, Ph.D.
University of California-San Francisco
Novel microbiota-derived molecules that modulate the host immune response

De'Broski R. Herbert, Ph.D.
University of California-San Francisco
Trefoil factor proteins modulate host immunity against hookworms

Tobias M. Hohl, M.D., Ph.D.
Memorial Sloan-Kettering Cancer Center
Tracing innate control over respiratory and systemic fungal infection

Alexei V. Korennykh, Ph.D.
Princeton University
Systems analysis of pathogen defense mediated by 2', 5'-linked isoRNA

Matthias Marti, Ph.D.
Harvard University
Cellular communication in malaria parasites

Erika L. Pearce, D.Phil., Ph.D.
Washington University
Cellular metabolism in immunity to infection

Manuela Raffatellu, M.D.
University of California-Irvine
Characterization of novel populations of neutrophils during bacterial infection

Daniel B. Stetson, Ph.D.
University of Washington
Why do DNA viruses cause cancer?

Niraj H. Tolia, Ph.D.
Washington University School of Medicine
Molecular basis for and inhibition of red blood cell invasion by Plasmodium parasites

Victor J. Torres, Ph.D.
New York University School of Medicine
Staphylococcus aureus pore-forming toxins: leukocyte killing and beyond

Robert T.  Wheeler, Ph.D.
University of Maine
Phagocytes block fungal dimorphism to defend the epithelial barrier


Abraham Brass, M.D., Ph.D.
University of Massachusetts Medical School
Defining dengue virus’s dependencies: discovery and characterization of host factors required for viral replication

Dustin Brisson, Ph.D.
University of Pennsylvania
Evolution of original antigenic sin in Lyme disease

Michael Federle, Ph.D.
University of Illinois-Chicago
Interspecies communication among commensal and pathogenic bacteria

Xiarong Lin, Ph.D.
Texas A&M University
Fungal communication and pathogenicity

Suzanne Noble, M.D., Ph.D.
University of California-San Francisco
Discovery of a cell type switch that drives fungal-mammalian commensalism

Sara Sawyer, Ph.D.
University of Texas-Austin
Genetics of viral species tropism

Emily Troemel, Ph.D.
University of California-San Diego
Microsporidia virulence factors exploit host cell physiology

David Weiss, Ph.D.
Emory University
Novel RNAi-like system controls bacterial innate immune evasion and virulence

Felix Yarovinsky, M.D.
University of Texas Southwestern Medical Center
TLR-independent host resistance to protozoan parasites

Liang Zhou, M.D., Ph.D.
Northwestern University
Environmental impact on host-pathogen interaction


Neal M. Alto, Ph.D.
University of Texas Southwestern Medical Center
Systems architecture of bacterial effector/host membrane interactions

Anna I. Bakardjiev, M.D.
University of California-San Francisco School of Medicine
Pregnancy-related pathogenicity determinants of Listeria monocytogenes

Juliane Bubeck Wardenburg, M.D., Ph.D.
University of Chicago
Tuning of the host-bacterial interaction by a pore-forming toxin

Carolyn B. Coyne, Ph.D.
University of Pittsburgh School of Medicine
Actin cytoskeleton and antiviral innate immune signaling

Sarah M. Fortune, M.D.
Harvard University
Quick change: polarity, diversity and virulence in Mycobacterium tuberculosis

Chyi-Song Hsieh, M.D., Ph.D.
Washington University School of Medicine
Host discrimination between pathogenic and commensal bacteria in the colon

Jonathan C. Kagan, Ph.D.
Harvard Medical School
Novel approaches to study RIG-I like receptor mediated antiviral immunity

Julie K. Pfeiffer, Ph.D.
University of Texas Southwestern Medical Center
How gut microbes enhance enteric virus infectivity

Christopher S. Sullivan, Ph.D.
University of Texas-Austin
Herpes virus immune evasion via non-coding RNA regulatory elements

Sing Sing Way, M.D., Ph.D.
University of Minnesota Medical School
Maternal regulatory T cells control the immune pathogenesis of prenatal infection