Thomas R. Hawn, M.D., Ph.D. University of Washington Variation and regulation of innate immunity to Mycobacteria

Robert O. Heuckeroth, M.D., Ph.D. Washington University Genetic and non-genetic risk for Hirschsprung disease

Ari Melnick, M.D. Weill Medical College of Cornell University Differentiation therapy for B-cell lymphomas

Stephanie Ware, M.D., Ph.D. University of Cincinnati Uncovering novel genetic causes and risks in congenital heart disease patients

Mark S. Anderson, M.D., Ph.D. University of California-San Francisco Translating AIRE-control of immune tolerance to human autoimmunity

Kathleen L. Collins, M.D., Ph.D. University of Michigan-Ann Arbor Viral mechanisms of persistence in HIV infected people

Laurence Cooper, M.D., Ph.D. University of Texas M.D. Anderson Cancer Center Tumor-specific alloantigen-anergic donor-derived T-cell therapy after hematopoietic stem-cell transplantation

William M. Grady, M.D. University of Washington Fred Hutchinson Cancer Research Center Novel biomarkers for the prevention and treatment of colon cancer

S. Ananth Karumanchi, M.D. Harvard Medical School Soluble endoglin in the pathogenesis and prediction of preeclampsia

Francis Lee, M.D., Ph.D. Weill Medical College of Cornell University Role of BDNF in therapeutic strategies for affective disorders

Ernst R. Lengyel, M.D., Ph.D. University of Chicago Development of novel therapeutic and diagnostic strategies for ovarian cancer

Daniel L. Marks, M.D., Ph.D. Oregon Health and Science University Maternal nutrition and fetal metabolic programming

Jonathan R. Pollack, M.D., Ph.D. Stanford University Pathogenesis and diagnosis of clinically-indolent prostate cancer

Theodora S. Ross, M.D., Ph.D. University of Michigan-Ann Arbor Abnormal HIP1 and cancer biology

Jeffrey A. Toretsky, M.D. Georgetown University Novel cancer therapeutics based upon oncogenic fusion-protein transcription factors

Edus H. Warren, M.D., Ph.D. University of Washington Fred Hutchinson Cancer Research Center Toward immune therapy for colon cancer: identification of antigens recognized by CD8 + T lymphocytes on colon cancer stem cells

Kang Zhang, M.D., Ph.D. University of Utah Define novel genes for diabetic microvascular complications

Jayakrishna Ambati, M.D. University of Kentucky Suppression of angiogenesis

Kenneth Cusi, M.D. University of Texas-San Antonio Health Science Center Non-alcoholic fatty liver disease in type 2 diabetes: a novel intervention strategy targeting metabolic & molecular defects

Michael S. Diamond, M.D., Ph.D. Washington University Epitope-based immunogens and diagnostics for dengue virus

Anna Huttenlocher, M.D. University of Wisconsin-Madison Diagnosis and treatment of autoinflammatory disease

Branch Moody, M.D. Harvard Medical School Human T-cell responses to CD1 and lipid antigens from M. tuberculosis

Annabelle Rodriguez, M.D. Johns Hopkins University School of Medicine Deficiency of the lipoprotein receptor, scavenger receptor class B type I, in women with infertility

Norman E. Sharpless, M.D. University of North Carolina-Chapel Hill The p16INK4 a tumor suppressor in stem cell aging

Warren D. Shlomchik, M.D. Yale University Memory T cells for improved immune reconstitution and GVL in allogeneic hematopoietic stem cell transplantation

Pradeep Singh, M.D. University of Washington Gallium as an antimicrobial and anti-biofilm agent: a trojan horse strategy that disrupts bacterial iron metabolism

Russell Van Gelder, M.D., Ph.D. Washington University Pathogenesis of inflammatory eye disease

Richard J. Auchus, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas Pharmacogenomics of hypertension Arul M. Chinnaiyan, M.D., Ph.D. University of Michigan-Ann Arbor Autoantibody profiles for cancer diagnosis, prognosis, and therapy Bruce E. Clurman, M.D., Ph.D. University of Washington Fred Hutchinson Cancer Research Center Diagnostic and therapeutic approaches to cell cycle-associated cancer Dean Y. Li, M.D., Ph.D. University of Utah Therapeutic potential of vascular guidance cues Ali J. Marian, M.D. Baylor College of Medicine Molecular genetics and pathogenesis of human arrhythmogenic right ventricular cardiomyopathy/dysplasia Kerry J. Ressler, M.D., Ph.D. Emory University Neurobiology of fear, neuroplasticity and posttraumatic stress disorder Charles M. Rudin, M.D., Ph.D. Johns Hopkins University Novel therapeutic strategies for small cell lung cancer Jean E. Schaffer, M.D. Washington University Lipotoxic cardiomyopathy: from molecular mechanisms to human disease William Weiss, M.D., Ph.D. University of California-San Francisco Combination therapy against EGFR and PI3-kinase in glioma Cassian Yee, M.D. University of Washington Fred Hutchinson Cancer Research Center Adoptive therapy of cancer: strategies to augment the antigen-specific T cell response

Richard J. Auchus, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas Pharmacogenomics of hypertension Arul M. Chinnaiyan, M.D., Ph.D. University of Michigan-Ann Arbor Autoantibody profiles for cancer diagnosis, prognosis, and therapy Bruce E. Clurman, M.D., Ph.D. University of Washington Fred Hutchinson Cancer Research Center Diagnostic and therapeutic approaches to cell cycle-associated cancer Dean Y. Li, M.D., Ph.D. University of Utah Therapeutic potential of vascular guidance cues Ali J. Marian, M.D. Baylor College of Medicine Molecular genetics and pathogenesis of human arrhythmogenic right ventricular cardiomyopathy/dysplasia Kerry J. Ressler, M.D., Ph.D. Emory University Neurobiology of fear, neuroplasticity and posttraumatic stress disorder Charles M. Rudin, M.D., Ph.D. Johns Hopkins University Novel therapeutic strategies for small cell lung cancer Jean E. Schaffer, M.D. Washington University Lipotoxic cardiomyopathy: from molecular mechanisms to human disease William Weiss, M.D., Ph.D. University of California-San Francisco Combination therapy against EGFR and PI3-kinase in glioma Cassian Yee, M.D. University of Washington Fred Hutchinson Cancer Research Center Adoptive therapy of cancer: strategies to augment the antigen-specific T cell response

Andrew D. Badley, M.D., F.R.C.P. Mayo Clinic Rochester Novel antiapoptotic therapies for sepsis

Kenneth R. Cooke, M.D. University of Michigan Medical School Acute lung injury after SCT: from laboratory insights to novel strategies for diagnosis and treatment

James E. Crowe, Jr., M.D. Vanderbilt University School of Medicine Immunology and cell biology of human metapneumovirus infections

Dean W. Felsher, M.D., Ph.D. Stanford University School of Medicine Pre-clinical validation of g-quadruplex drugs that target MYC to treat cancer

Joseph G. Gleeson, M.D. University of California-San Diego School of Medicine Causes and pathogenesis of cerebellar malformation syndromes in humans: bedside to bench

Jeffrey S. Glenn, M.D., Ph.D. Stanford University School of Medicine Hepatitis C virus: from molecular virology to effective pharmacologic eradication

Richard J. O’Brien, M.D., Ph.D. Johns Hopkins University School of Medicine Alzheimers disease and synaptic transmission

George Q. Daley, M.D., Ph.D. Children's Hospital Boston Harvard Medical School Chemotherapy and stem cell transplantation in leukemia

Jane E. Koehler, M.D. University of California-San Francisco School of Medicine Genomic and clinical correlates of human Bartonella quintana infection

David M. Markovitz, M.D. University of Michigan-Ann Arbor New approaches to inhibiting HIV replication

Sofia D. Merajver, M.D., Ph.D. University of Michigan-Ann Arbor Genetic determinants of aggressive breast cancer phenotypes: translation to the clinic

Cam Patterson, M.D. University of North Carolina-Chapel Hill School of Medicine Oxidative profiles in cardiovascular diseases

Donald Small, M.D., Ph.D. Johns Hopkins School of Medicine Translating FLT3 inhibition into improved therapy for pediatric AML and infant ALL

David M. Altshuler, M.D., Ph.D. Massachusetts General Hospital Genomic approaches to the genetics of type 2 diabetes and response to antidiabetic medication

Judy H. Cho, M.D. University of Chicago Pritzker School of Medicine Characterization of expression patterns in monocyte-derived cells in inflammatory bowel disease

Barry A. Finette, M.D., Ph.D. University of Vermont College of Medicine Mechanisms of malignant transformation in humans

Thomas J.Hudson, M.D. McGill University Faculty of Medicine Genomic approaches to identify genes predisposing to asthma

Jonathan D. Licht, M.D. Mt. Sinai School of Medicine Targeting aberrant repression as a therapeutic strategy in hematological malignancy

Hector D. Molina, M.D. Washington University School of Medicine Mechanisms of complement-induced abnormalities in fetomaternal tolerance

David T. Scadden, M.D. Massachusetts General Hospital Developing control mechanism-based stem cell therapies

Sunil K. Ahuja, M.D. University of Texas Health Science Center-San Antonio HIV-1 AIDS pathogenesis: bridging the gap between host genotype and HIV transmission/disease phenotype

Cameron S. Carter, M.D. University of Pittsburgh School of Medicine Multimodal brain imaging and the pharmacotherapy of cognitive disability in schizophrenia

Jeffrey A. Drebin, M.D., Ph.D. Washington University School of Medicine Targeted suppression of beta-catenin in colorectal cancer

Glenn I. Fishman, M.D. Mount Sinai School of Medicine Gap junction channels as novel anti-arrhythmic targets

Lisa M. Guay-Woodford, M.D. University of Alabama-Birmingham School of Medicine Genetic modifiers in recessive polycystic kidney disease: implications for pathogenesis and therapeutics

Marshall S. Horwitz, M.D., Ph.D. University of Washington School of Medicine Therapeutic inhibition of aberrant protease activity in inherited neutropenias

Elizabeth M. McNally, M.D., Ph.D. University of Chicago Microvascular spasm in the progression of cardiomyopathy

Anthony J. Muslin, M.D. Washington University School of Medicine Signaling mechanisms in cardiovascular disease

Steven A. Porcelli, M.D. Albert Einstein College of Medicine Defining the protective human CD8+ T-cell response against Mycobacterium tuberculosis

Marc E. Rothenberg, M.D., Ph.D. University of Cincinnati College of Medicine Experimental analysis

Robert B. Darnell, M.D., Ph.D. Rockefeller University Detection and activation of tumor-specific killer cells in animal models and cancer patients

Brian J. Druker, M.D. Oregon Health Sciences University Mechanism-based therapy for chronic myelogenous leukemia

Thomas F. Gajewski, M.D., Ph.D. University of Chicago Pritzker School of Medicine Development of a second generation melanoma vaccine

Daniel C. Javitt, M.D., Ph.D. New York University School of Medicine NMDA-based treatment development for schizophrenia

Joseph M. McCune, M.D., Ph.D. University of California-San Francisco School of Medicine Gladstone Institute of Virology and Immunology Regulation of human thymic function in vivo

M. Juliana McElrath, M.D., Ph.D. University of Washington School of Medicine Fred Hutchinson Cancer Research Center Induction of cellular immunity in HIV-1 exposed seronegative individuals

Mark R. Philips, M.D. New York University School of Medicine Endomembrane trafficking of Ras: novel molecular targets for anticancer agents

Daniel J. Rader, M.D. University of Pennsylvania School of Medicine Novel therapeutic approach to atherosclerosis through modulation of HDL metabolism

Don C. Rockey, M.D. Duke University Medical Center The cellular and molecular basis of portal hypertension: an endothelialopathy in cirrhosis

Nina Bhardwaj, M.D., Ph.D. Rockefeller University Vaccination of HIV-1 positive individuals by antigen-pulsed dendritic cells

Eva Guinan, M.D. Harvard Medical School Dana Farber Cancer Institute Extending the donor pool by inducing alloantigen specific T-cell anergy ex vivo for human hematopoietic stem cell transplantation

Barbara Hempstead, M.D., Ph.D. Weill Medical College of Cornell University Growth factor regulation of coronary angiogenesis

Jason M. Morrow, M.D. Vanderbilt University School of Medicine Isoprostanes as markers and mediators of oxidant stress in humans

W. Edward Robinson Jr., M.D., Ph.D. University of California-Irvine College of Medicine Structure-function analyses of clinically relevant HIV integrases

Antony Rosen, M.B., Ch.B. Johns Hopkins University School of Medicine Altered structure and clearance of autoantigens during apoptosis: implications for autoimmunity

Ann Marie Schmidt, M.D. Columbia University College of Physicians and Surgeons Novel therapeutic strategy for the prevention and treatment of diabetic complications: antagonism of receptor for advanced glycation end products

Mark H. Siegelman, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas Functionally activated lymphocyte CD44 in the initiation and perpetuation of autoimmune disease

Dennis J. Templeton, M.D., Ph.D. Case Western Reserve University School of Medicine Stress signaling inhibitors potentiate genotoxin-induced apoptosis in a human colon tumor model

Gilbert Chu, M.D., Ph.D. Stanford University Medical Center Cancer treatment by genome-wide transcription scanning

Claire M. Doerschuk, M.D. Case Western Reserve University School of Medicine The response of neutrophils during inflammatory lung disease

Robert W.Doms, M.D., Ph.D. University of Pennsylvania School of Medicine Chemokine receptors as new targets for HIV-1 therapeutics

Erol Fikrig, M.D. Yale University School of Medicine Borrelia gene expression and lyme arthritis

Alex E. MacKenzie, M.D., Ph.D. University of Ottawa Faculty of Medicine The cytoprotective NAIP and XIAP genes: identification of activation pathways and inducing agents

Howard A. Rockman, M.D. Duke University Medical Center Novel molecular therapeutic strategies in heart failure: role of beta-adrenergic receptor desensitization

Christian W. Schindler, M.D., Ph.D. Columbia University College of Physicians and Surgeons Intervention of IL-5 signaling: a therapeutic paradigm for asthma

Joyce M. Slingerland, M.D., Ph.D. University of Miami School of Medicine Resistance to tamoxifen: a consequence of altered p27Kip1 regulation during breast cancer progression

Mark J. Yeager, M.D., Ph.D. Scripps Research Institute Structure and function of cardiac gap junction membrane channels

Hagop Youssoufian, M.D. Baylor College of Medicine Transcellular gene therapy: application to Fanconi anemia