Career Awards at the Scientific Interface

Application Deadline

Jan 12, 2026

Status

Invited Applicants Only

Grant Information

BWF's Career Awards at the Scientific Interface (CASI) provide $560,000 over five years to bridge advanced postdoctoral training and the first three years of faculty service. These awards are open to U.S. and Canadian citizens, permanent residents, and temporary residents.

The Burroughs Wellcome Fund launched the Career Awards at the Scientific Interface in 1999 to foster the early career development of researchers who are transitioning from training environments in the physical, mathematical, computational sciences and/or engineering into postdoctoral work in the biological sciences, and who are dedicated to pursuing a career in academic research.

Please visit this video overview of the CASI program for more information from Program Officer Dr. Tammy Collins.

Progress Reporting

Due Date: October 1

Progress and financial reports are required of all BWF grants and are due on the date(s) specified in the award letter or agreement. The Advisory Committee and staff depend heavily upon progress and financial reports to evaluate progress. Late reports inconvenience advisory committee reviewers and impede BWF's evaluation of its programs. Failure to submit progress or financial reports in a timely fashion will result in payments being withheld, and if submissions are missed repeatedly, the award will be terminated.

BWF provides the following progress report guidelines to assist in preparing and submitting progress reports in an acceptable manner. The progress report and financial updates are to be submitted through Proposal Central. After logging in to Proposal Central, you can find the required deliverables on the home page. Failure to submit any portion of the report by the due date will interrupt or cancel your funds.

If you need help using Proposal Central, please follow their Customer Service webpage instructions to contact their tech support team.

Progress Reporting for Awardees

Due Date:  October 1

Progress Report

The progress report requires the awardee to submit a written report on the progress of the original or approved update to research project aims, an updated biographical sketch, a sponsor letter of evaluation (see template linked below), and any recent publications. The awardee must also complete and upload the activity report (see template linked below). Details regarding each section are in Proposal Central. The progress report must be submitted annually on October 1st.

Financial Report

Awardees must update award spending in the Proposal Central budget summary; awardees should report spending in the “expenses” column. Details regarding financial reporting are in Proposal Central. Financial reports are due annually on October 1st.

Report Format

All progress and financial reporting materials should be submitted through Proposal Central. If you have questions, please contact our Program Coordinator, Lama Haidar (lhaidar@bwfund.org).

No-Cost Extension Requests

Awardees may request a no-cost extension (i.e., no additional grant funds to be provided) at least 30 days before the grant end date. To begin a no-cost extension request, please email our Program Associate, Eliza Gary (egary@bwfund.org), with a short description of the purpose for which the extension is requested. The request for a no-cost extension must be copied to the investigator and the appropriate representative of the investigator’s institution. The BWF team will then add an official no-cost extension request to your award on Proposal Central; the awardee should include a detailed explanation of the purposes for which the extension is requested. Directions are outlined in the award agreement “General Terms and Conditions” and included in Proposal Central.
 
In general, extensions do not exceed 24 months. The Fund reserves the right to deny a request in whole or in part. If the request is approved, the named investigator and his/her institution will be incumbent upon to provide annual progress and expenditure reports each year of the no-cost extension period and final progress and financial reports at the end of the no-cost extension period. BWF will request a return of all no-cost extension funds if progress report requirements and deadlines are unmet.
 

Forms:

General

Can I submit more than one application?
No. However, you may simultaneously submit an application to another BWF program if you meet the eligibility criteria for that program. If you happen to be selected as a finalist for two BWF programs at once, you must choose which to accept since awardees may not hold more than one BWF award simultaneously.


Do you pay indirect costs?
No.


What date should I use as having received my Ph.D.?
You can use either the date of your Ph.D. defense or the date your degree was conferred by your institution.


The eligibility requirements mention that a candidate must be based at a non-profit institution [501(c)(3) or equivalent] in the U.S. or Canada. What is a 501(c)(3)?
According to the U.S. Internal Revenue Code, a 501(c)(3) organization is an American tax-exempt, nonprofit organization. Almost all degree-granting institutions are classified as such, as are most research institutes. You will need to check with your institutional officials, usually called the grants and contracts office or the sponsored programs office, etc., to confirm your institution’s classification. BWF cannot make this determination for you.


How do I return to an incomplete application that I saved, but have not yet submitted?
To access a saved application, return to the ProposalCentral system, login, and access the Letter of Intent on the "Proposals" tab. The Letter of Intent may be edited until the application deadline.


Can I change my application once submitted?
You have the option to unsubmit the application before the deadline. However, you must resubmit your application before the deadline for the Letter of Intent (or full proposal application, if invited) to be considered. Once the deadline has passed, no further changes will be permitted.


What is a “signature block”?
A signature block is found at the end of a letter and includes the letter writer’s name, title(s), department(s), and institution. It is usually found just after the closing of the letter (e.g., just after the word “Sincerely,’ or ‘Yours truly,’) and just under the letter writer’s signature. Here’s an example of a signature block:

Jane Smith, Ph.D.
Chair and Professor, Department of Physics
ABC University


Do I need to include citations and references in the essay of the proposed work?
No. Citations and references are not required in the Letter of Intent and should not be included. If you are invited to submit a full application, citations and references can be included in the optional Bibliography attachment.


I understand that I can propose research with up to two collaborators. Does the collaborator(s) need to be located at my institution? Can a collaborator(s) be located elsewhere? Is it ok if the collaborator(s) is located outside of the US and Canada?
If you are invited to submit a full proposal application, applicants may propose partnering with up to two collaborators in their research plan. Applicants may work with collaborators at other institutions as well as those outside of the US and Canada. Note that partnering with a collaborator(s) is entirely optional. If you choose to propose work with a collaborator(s), you must include in your full proposal application: 1) a letter of collaboration; and 2) the collaborator(s) curriculum vitae (CV) or biosketch.

Eligibility

How do I determine if I am eligible to submit a Letter of Intent? What is the first step?
Review eligibility in the Request for Proposal.


Can I contact BWF to determine my eligibility?
It is the responsibility of applicants to read the published Request for Proposals guidelines and FAQs to determine eligibility. BWF staff will do their best to respond to every inquiry but will prioritize those questions that are not already clearly addressed in the published guidelines. Please do not contact BWF to ask if we can make an exception to clearly stated guidelines. Please read the eligibility requirements defined in the Request for Proposals and FAQs carefully before contacting BWF.


Which Ph.D. fields are eligible?
Candidates must hold a Ph.D. degree in one of the fields of mathematics, physics, chemistry, computer science, statistics, or engineering. This includes related areas of physical, mathematical, computational, theoretical, and engineering science. Exceptions will be made only if the applicant can demonstrate significant expertise in one of these areas, evidenced by publications, undergraduate major, or master’s degree. You must have this exception approved by the program officer before applying.


I hold or have accepted an NIH K99/R00 award, or another postdoc-to-faculty transition award, such as the HHMI Hanna Gray Fellowship. Can I apply for this program?
No.


I have applied to the NIH K99/R00 program and/or other postdoc-to-faculty transition award programs, but the awards have not been selected. Can I apply to the BWF CASI program?
Yes. However, awardees cannot receive funding simultaneously from both a K99 (or other postdoc-to-faculty transition award) and a CASI award.


I have not yet decided whether I will pursue a full-time career in research as an independent investigator at a non-profit institution [501(c)(3) or equivalent] in the U.S. or Canada. Can I apply to this program?
No.


My Ph.D. is in biochemistry/biophysics/biology/cell biology/etc. Am I eligible?
Possibly. The Career Awards at the Scientific Interface program is designed to support those working in biology with backgrounds in the physical/mathematical/computational or engineering sciences. If you can show evidence of significant accomplishment or competence in one of those areas (i.e., papers published, advanced coursework, or undergraduate major), and if your proposal draws on that background, you are eligible. You will need to make a case that your work is truly interdisciplinary and makes use of non-biological approaches.


I hold an M.D. Am I eligible to apply to the CASI program?
Possibly. If you hold both an M.D. and a Ph.D., and your Ph.D. is in one of the fields of mathematics, physics, chemistry, computer science, statistics, or engineering, you are eligible. This includes related areas of physical and computational science. Exceptions will be made only if the applicant can demonstrate significant expertise in one of these areas, evidenced by publications, undergraduate major, or master’s degree. In addition, you cannot have spent more than 60 months in postdoctoral research since receipt of your Ph.D. If you hold an M.D. without also holding a Ph.D., you are not eligible to apply to this program. Instead, you may want to consider applying to the Career Awards for Medical Scientists program.


Can I send my CV/biosketch to BWF to determine eligibility?
No, due to the high volume of inquiries, BWF cannot evaluate each candidate’s CV/biosketch to confirm eligibility. Please read the eligibility requirements and FAQs carefully before contacting BWF.


My work experience since receiving my Ph.D. exceeds the 60-month limit. However, my work has not always been as a postdoc. At present, I am working in a postdoctoral position. Am I eligible?
If your entire work experience since receiving your Ph.D. has been in any scientific research field (including outside academia) and exceeds 60 months, you are not eligible. However, if part of your work experience was not in a science research field, and your scientific work experience doesn’t exceed 60 months, you are eligible.


I’m a temporary resident of the U.S. or Canada. Am I eligible for the award?
Possibly. If you are a temporary U.S. or Canadian resident and you hold a valid visa that allows you to remain in the U.S. or Canada during the postdoctoral period of the grant, you are eligible. If a grant is awarded and your visa does not allow for such a stay, BWF may terminate the grant. BWF will not intercede on behalf of non-citizens whose stay in the U.S. or Canada may be limited by their visa status. If you are invited to submit a full application, your institution must verify your immigration status as part of your application.


I am a postdoc at an independent research institute, teaching hospital, or similar type of institution. Am I eligible for a career award?
Possibly. Your institute must be a non-profit institution [501(c)(3) or equivalent] in the U.S. or Canada, and your primary postdoctoral mentor must hold an appointment at the same institution. Additionally, your institution must have organizational representatives that receive and process grant agreements as we make the grant to the institution on your behalf. If these criteria are met, you are eligible to apply. With the exception of eligible postdoctoral fellows at the National Institutes of Health, Letters of Intent will not be accepted from federal facilities. These policies are non-negotiable.


My title is not "postdoctoral fellow". Am I eligible for the award?
Possibly. You are eligible if (1) you have at least 12 months, but not more than 60 months of postdoctoral research experience, including time as, for example, an instructor, research associate, or non-tenure track research faculty, and (2) you meet all other eligibility requirements.


I have two postdoc mentors. Can I still apply?
Yes. One of the mentors will need to be the primary mentor. The primary mentor will be the one who can certify the Letter of Intent and provide a recommendation letter. Only one recommendation letter can be submitted. If necessary, your primary and secondary mentor can provide a joint letter to be submitted by the primary mentor. If your mentors are at two different institutions, the primary mentor should be the one located at the institution where you will be doing the proposed work (the institution you will enter on the "Nominating Institution" page of the online application).


Do I need a commitment from a university for a faculty appointment to apply for this award?
No. The purpose of the award is to help postdoctoral scientists obtain a faculty appointment at an institution of their choosing. Candidates may be applying for faculty positions at the same time of application, but if you currently hold or have accepted, either verbally or in writing, a tenure-track faculty appointment, you are not eligible.


I have publications from my graduate (and undergraduate) studies, but I am not the first author of any of them. Am I eligible to apply?
No. You must have at least one first-author publication to be eligible to apply for this program. This includes papers on which "first authorship" is shared.


I have submitted a first-author manuscript from my graduate (or undergraduate) studies, but it has not yet been published. Am I eligible to apply?
Possibly. If the manuscript is accepted for publication or in press, you are eligible to apply – otherwise, you are not eligible.

Accessing the Application

Can I add a postdoc mentor if I am invited to submit a full application?
You may add a mentor, but you may not change the primary mentor whose name is associated with your Letter of Intent.


What if I plan to start a faculty position in the fall, after the Letter of Intent deadline and before the full application deadline?
This award cannot be made to a tenure-track faculty member, because it is a transition award. If you are planning to start a faculty position before the award begins, you are not eligible to apply.


What if I plan to start a faculty position in the spring, after the full application deadline and before the interview?
This award cannot be made to a tenure-track faculty member, because it is a transition award. If you are planning to start a faculty position before the award begins you are not eligible to apply.


Do I need to complete an application in one session?
No, you can start an application and return at a later time to complete the application. When beginning a new application, you are required to establish a login and password. At any time during the application process, you may click the "save and close" button, exit the application, and return at a later time.


If one of my publications gets accepted after the Letter of Intent, full application deadline, or interview, how can I inform the Advisory Committee of this?
After each deadline, you may no longer amend your application, including updates to a publication or the addition of a new publication. Applications are turned around quickly to the advisory committee for review; you can provide the latest updates on the progress of your research at each phase of application process, including the final interview phase.


After submitting a Letter of Intent, can I change my mentor or institution if I am invited to submit a full proposal?
No. Invitations to submit a full application are based on the information submitted in the Letter of Intent.


When will I be notified as to whether I have been selected to submit a full application?
Applicants who submitted a Letter of Intent will be notified via email by the date stated in the Request for Proposals.


Can I include submitted manuscripts in the list of publications?
No. Only papers that have been published or are "in press" (accepted for publication) should be included. Pre-prints, however, such as through bioRxiv or arXiv, are allowable as one of your five publications. The requirement for one first-author publication still applies.

Letter of Intent

Do I need to submit a Letter of Intent prior to submitting a full application?
Yes. All applicants to the program must submit a Letter of Intent as the first step. Not everyone who submits a Letter of Intent will necessarily submit a full application. Letters of Intent will be reviewed by the Advisory Committee and selected candidates will be invited to submit a full application.


My postdoc mentor and graduate advisor are the same person. For the LOI application portal, should I list their name under each section?
Yes, you may list them as both – the Postdoc Mentor Recommendation Letter is required for the LOI, and the Graduate Advisor’s name only is required for the LOI. If invited to submit a full proposal, the Graduate Advisor is required to submit a Recommendation Letter. However, in this case, we would provide flexibility, allowing you to choose to have your PhD/graduate thesis committee chair (or other committee member) submit the letter jointly with your graduate/postdoctoral mentor regarding work completed during your graduate phase.


I have publications from my graduate (and undergraduate) studies, but they are not necessarily relevant to the research I am proposing in the application. Should I include them on the application form?
Yes. Up to five of your top publications should be included in the Letter of Intent, even if they are not relevant to the research being proposed.


Can letters of collaboration be included in the Letter of Intent?
No.


Do I need to submit a proposed budget with my Letter of Intent?
No.


My visa is not valid for more than one year, but I need a new “position offer” to get a new visa. Do you ask for a valid two-year visa (for the postdoc period) when submitting the Letter of Intent?
We understand that not all U.S. visas will cover the full two years of postdoc for the award. For this reason, we are not asking for a valid two-year visa when submitting the Letter of Intent. If you are invited to submit a full application, BWF requires that your institution certify that you hold a current valid U.S. visa and that the institution will manage your residency status during the postdoctoral period of the award (perform all necessary paperwork to extend visa status). More information will be provided if an invitation is sent to you.


Can I include figures, tables, graphs, diagrams, and/or pictures in the section of the Letter of Intent asking for an essay of the proposed work?
No.


I have been invited to submit a full proposal application and have had developments in my research since my LOI submission, can I change my title?
We do not allow title changes after the LOI other than correcting grammatical errors or typos. If you have had developments in your research that you want to make clear to the review committee, you should explain the new developments in your proposal.


Do I need to be nominated by my institution to submit a Letter of Intent?
No.

Recommendation Letter

To whom should my recommendation letter be addressed?
The letter of recommendation should be addressed to the CASI Advisory Committee and must be uploaded to your application by the letter writer prior to submission by the deadline. Emailed or hard copy letters will not be accepted.


What is a “graduate advisor” and do they need to submit a Recommendation Letter?
Your graduate advisor is the individual who mentored you when you trained to obtain your Ph.D./doctoral degree—otherwise known as a “Ph.D. advisor.” We ask you to list their name during the Letter of Intent phase, but they do not submit a recommendation letter during this phase. If invited to submit a full application, your graduate/Ph.D. The advisor will submit a letter of recommendation at that time.


What should be included in the recommendation letter?
The primary postdoctoral mentor should describe your qualifications and potential for contributing to biomedical science, highlighting specific skills or expertise in a scientific discipline other than biology. The letter should also describe the research environment in which you will work, your mentoring plan, the number of graduate students and postdoctoral fellows in the lab, and the supporting services to be provided by the institution.


How can I submit my recommendation letter?
Since the recommendation letter must remain confidential, the recommender (your primary postdoc mentor) must upload their own letter to your application before the application deadline. For this process to work properly, you must send an email from within your application to your primary postdoctoral mentor requesting the letter. The email will contain a link that is specific to your application and your primary postdoctoral mentor. For detailed instructions on how to request a confidential letter from your primary postdoctoral mentor, see the instructions included in the Request for Proposals document.


Can the recommendation letter be sent separately?
No. Letters of recommendation must be uploaded by the letter writer before submission of your application. An application can only be submitted when it is complete; therefore, it is highly recommended that the recommendation letter be uploaded to the application at least a week or more before the deadline. Emailed or hard-copy letters will not be accepted.


I have two postdoctoral mentors. Can I submit two recommendation letters?
Only one recommendation letter may be submitted with your LOI application. This letter should be from the person designated as your primary postdoctoral mentor in the application. However, if both mentors wish to write and co-sign one letter, that is acceptable. Two letters will not be accepted.

Logistics

I completed my application. How do I submit it?
Once the application has been completed and the mentor has completed the letter of recommendation and certification information:

  • Click "Validate" on the application sidebar.
  • If the application is not missing the required items, click the "Submit" link on the sidebar and hit the "Submit" button on the page.
  • If any items are still missing, a list will appear at the top of the page. Otherwise, you will receive a message that the Letter of Intent is submitted. If you do not, please contact ProposalCentral tech support.

I forgot my user ID/password. What should I do?
For a forgotten password or user ID, access the ProposalCentral login screen and click the forgotten password link.


If I have questions about a particular program guideline or the electronic application, whom can I contact for help?
For problems with the electronic application, please contact the ProposalCentral help desk at pcsupport@altum.com. For questions regarding eligibility, please email casi@bwfund.org.

2025

Scott Albert, PhD
University of North Carolina at Chapel Hill
Mapping Whole-Brain Motor Resilience Across the Lifespan
 
A’Lester Allen, PhD
University of Illinois-Chicago
Minimal Modification, Maximum Insight: Next-Generation Peptide Imaging in Vivo
 
Maya Anjur-Dietrich, PhD
Massachusetts Institute of Technology
Physical Biology of Biofilms: From Single Cells to Global Processes
 
Margaret Billingsley, PhD
Massachusetts Institute of Technology
Developing Nanoparticle Platforms to Overcome Ovarian Cancer Heterogeneity
 
Nicholas Card, PhD
University of California-Davis
Understanding the Neural Basis of Speech and Restoring it with Brain-Computer Interfaces
 
Yitzhak Norman, PhD
University of California-San Francisco
Neural Dynamics of Verbal Memory Circuits in the Human Brain
 
Julia Rogers, PhD
Columbia University
Learning the Biophysical Logic of Cell Signaling
 
Akanksha Thawani, PhD
University of California-Berkeley
Programmable Genetic Supplementation by Harnessing Retroelements
 
Benjamin Winer, PhD
Memorial Sloan Kettering Cancer Center
Pushing the Envelope: Plasma Membrane Abundance as a Biophysical Regulator of Immune Cell Migration, Phagocytosis, NETosis, and Demyelination
 
Shiyu Xia, PhD
California Institute of Technology
Engineering Synthetic Protein Circuits to Program Cell Death and Immunity

2024

Lamiae Abdeladim, PhD
University of California-Berkeley
Pan-cortical Optical Brain Machine Interfaces for Complex Visual Percept Recreation
 
Lindsey Brown, PhD
Princeton University
Dynamical Systems and Control Approaches to Understanding and Shifting Individual Learning Trajectories in the Emergence of Neuropsychiatric Disease
 
Gregg Castellucci, PhD
New York University
Understanding Human Communication Using Neural, Behavioral, and Comparative Approaches
 
Kate Cavanaugh, PhD
University of California—San Francisco
Working Against the Clock: Leveraging Biophysics to Extend Female Reproductive Lifespan
 
Colwyn Headley, PhD
Stanford University
Bioengineering Mitochondria for Targeted Delivery
 
Natsumi Komatsu, PhD
University of California-Berkeley
Mapping Neurochemistry of the Brain with Near-Infrared Nanosensors and Deep-Brain Microscopy
 
Deepak Krishnamurthy, PhD
University of California-Berkeley
Microscale Biophysics of the Ocean
 
Iain Martyn, PhD
University of California-San Francisco
Mapping Human and Mouse Morphogenetic Decisions During Development with CARTOGRAPHER
 
Harold McNamara, PhD
Princeton University
Guiding Stem Cell Self-Organization with Optogenetic Circuits
 
Aran Nayebi, PhD
Massachusetts Institute of Technology
Building Integrative, Embodied Agents to Understand Natural Cognition
 
Luca Rosalia, PhD
Stanford University
Bio-Fabrication and Mechanobiology: A Biomimetic Approach to Modeling and Understanding Cardiovascular Diseases
 
Shunzhi Wang, PhD
University of Washington
Computational Design of Enveloped Protein Capsids for Delivery

2023

Ismail Ahmed. PhD New York University Chemical Tools for Spatiotemporal Control and Detection of Neuropeptides in Behaving Animals

Linlin Fan. PhD Stanford University Probing synaptic and circuit plasticity mechanisms underlying learning and memory with all-optical electrophysiology

Avi Flamholz. PhD California Institute of Technology Predicting microbial CO2 production in global soils

Luis Hernandez-Nunez, PhD Harvard University The interoceptive balancing act: The neural computations underlying organ control

Richard Felix Horns, PhD California Institute of Technology RNA export for measurement and control of living cells

Carmel Howe, PhD Oregon Health & Science University Development of a low-cost 3D imaging system for rapid monitoring and targeted photorelease of ligands to identify driver neurons in the brain

Rebecca Pinals. PhD Massachusetts Institute of Technology A Multicellular Human Brain-on-Chip with Integrated Nanosensors to Visualize Neurodegenerative Disease Dynamics

Manuel Schottdorf, PhD Princeton University Deciphering cognition with geometry

Jessica Stark, PhD Stanford University Engineering Glycoimmunology

2022

William Edward Allen, Ph.D Harvard University Reverse-Engineering Brain Aging and Rejuvenation

Sima Asadi, Ph.D. Massachusetts Institute of Technology Pathogen-Laden Respiratory Droplet Formation via Mucosalivary Fluid Fragmentation

Diego Calderon, Ph.D. University of Washington Application of multiplex reporter assays towards understanding trans-acting gene regulation

Gregory Handy, Ph.D. University of Chicago Developing theoretical neuroscience frameworks to include plasticity from diverse brain cell types

Freeman Lan, Ph.D. University of Wisconsin-Madison Understanding complex microbial systems using ultrahigh-throughput experimentation, computational modelling, and machine-learning

Maijia Liao, Ph.D. Yale University Biophysics and Molecular determinants of morphological scaling laws in developing dendrites

Leenoy Meshulam, Ph.D. University of Washington Bridging scales: from microscopic neural circuitry to macroscopic function

Samantha Petti, Ph.D. Harvard University Uncovering remote evolutionary links with next-generation homology search

Boyang Qin, Ph.D. Princeton University Tracing gene expression of single cells across lineages during bacterial biofilm formation and dispersal

Liat Shenhav, Ph.D. Rockefeller University Early prediction of pregnancy disorders using the vasculature of the eye

Andrew Yang, Ph.D. University of California-San Francisco Molecular tools to decipher communication across the blood-brain barrier

2021

Kevin Dalton, PhD Harvard University Machine Learning Models for Next Generation X-Ray Diffraction Experiments

Rebecca Donegan, PhD Georgia Institute of Technology Heme as a nutrient source at the host-pathogen interface

Anne Draelos, PhD Duke University Adaptive Algorithms for Online Neural Modeling

Rogelio Hernandez-Lopez, PhD University of California-San Francisco A multiscale quantitative approach for engineering cellular therapies and disease modeling

Antentor Hinton, PhD University of Iowa Carver College of Medicine Reimaging, Restoring, and Repurposing Mitochondria and MERC networks

Christina Hueschen, PhD Stanford University Physical Biology of Parasites

Vira Kravets, PhD University of Colorado-Denver Beta cell networks and neural interactions in healthy and diabetic conditions

Ruth Marisol Herrera Perez, PhD Columbia University Engineering models to control cell communication in self-organizing systems

Rebecca Sherbo, PhD Harvard University Sustainable food out of thin air

Charlotte Strandkvist, PhD Harvard Medical School Studying cell fate decisions and dynamics with time-resolved single cell genomics

Longzhi Tan, PhD Stanford University Probing the 3D Chromatin and Spatial Transcriptomic Basis of Neurodevelopment, Social Behaviors, and Autism with Single-cell Precision

2020

Ahmed S. Abdelfattah, PhD Brown University Probing and manipulating the neural circuitry of opiate addiction using novel optogenetic tools

Zibo Chen, PhD California Institute of Technology Molecular programming using de novo designed proteins

Yogesh Goyal, PhD  University of Pennsylvania Biochemical trajectories guiding rare cell plasticity and therapy resistance in single cancer cells

Elizabeth R. Jerison, PhD  Stanford University Migration and population dynamics in the zebrafish adaptive immune system

Stephanie E. Lindsey, PhD Stanford University Quantitation of early great vessel growth and remodeling

Brittany S. Morgan, PhD TBD* Cracking the molecular recognition code: capturing dynamic substructures with small molecules

Cristina Rodriguez, PhD  University of California - Berkeley Decoding spinal cord neural circuits through advanced optical imaging methods

Julea Vlassakis, PhD University of California-Berkeley Precision oncology via single-cell proteomics

*award will be granted to faculty institution of award recipient

2019

Steven Mark Banik, PhD  Stanford University Reprogramming proteins for targeted degradation and intracellular trafficking

Jennifer Ann Noelani Brophy, PhD Stanford University Engineering organ development using synthetic genetic regulation

Fei Chen, PhD  Massachusetts Institute of Technology Genomic tools for understanding spatial and dynamic organization of biological tissues

Víctor García-López, PhD Rice University Molecular machines target, disrupt cell membranes, and kill cancer cells and resistant bacteria

Livnat Jerby, PhD  Massachusetts Institute of Technology Deciphering immune evasion mechanisms in cancer with single-cell technologies

Christina K. Kim, PhD  Stanford University Simultaneous molecular activity recording and transcriptomics of brainwide neural ensembles

Joseph William Larkin, PhD University of California-San Diego Patterning microbial populations through collective dynamics

Jeffrey E. Markowitz, PhD Harvard Medical School Resolving the neural mechanisms of reinforcement learning through new behavioral and optical technologies

Sergey D. Stavisky, PhD  Stanford University Brain-computer interfaces to actualize the movements and speech of people with paralysis

Jeffrey Robert Tithof, PhD University of Rochester Experimentally-validated simulations of cerebrospinal fluid flow through the brain’s perivascular network

Mark Wagner, PhD Stanford University Computations, recurrent dynamics, and learning in the cortex-cerebellum circuit underlying skilled behavior

2018

Gozde Durmus, DPhil, PhD Stanford University Levitating rare biological materials to decode the fundamentals

Kirsten L. Frieda, PhD California Institute of Technology Recording cell histories in situ using MEMOIR

Walter Gabriel Gonzalez, PhD California Institute of Technology Dynamic control of brain activity and behavioral robustness

Brandon Helfield, PhD University of Toronto Biophysics and cell biology of ultrasound-assisted membrane permeabilization for targeted gene delivery

Daniel R. Hochbaum, PhD Harvard Medical School Parsing learning-dependent circuit remodeling from spatiotemporally resolved cell states

Chiamaka Denise Okafor, PhD Emory University Targeting steroid receptors by uncovering evolutionary mechanisms of activation

Nicolas Christian Pegard, PhD University of California-Berkeley Computational optical interfaces for neurosciences and systems biology

Calin Plesa, PhD University of California-Los Angeles Ubiquitous biosensing through engineered histidine kinases

Silvia Rouskin, PhD Massachusetts Institute of Technology Understanding RNA structure heterogeneity and its role in gene expression and disease

Geoffrey Schiebinger, PhD Massachusetts Institute of Technology Analyzing developmental processes with optimal transport

Shahrzad Yazdi, PhD Massachusetts Institute of Technology Bridging the origin and function of flows in developmental biology

2017

Scott E. Boyken, PhD University of Washington Programmable protein interaction specificity to engineer and interrogate cellular signaling

Gregg A. Duncan, PhD Johns Hopkins University Microscale airway surface liquid interactions and their role in obstructive lung diseases

Felipe Garcia Quiroz, PhD Rockefeller University Repetitive elements of life: from genomes to proteins and material systems

Kelley Harris, PhD Stanford University Decoding the evolutionary history of DNA replication fidelity from whole genome sequences

Felix JH Hol, PhD Stanford University Eco-evolutionary dynamics of mosquito-borne viruses

Ashok Litwin-Kumar, PhD Columbia University Modeling distributed olfactory learning in rodents and insects

Po-Ru Loh, PhD Harvard School of Public Health Toward an early-warning system for leukemia: Characterizing mosaic copy number abnormalities

Tatiana V. Mishanina, PhD University of Wisconsin-Madison Visual-kinetic studies of pausing by bacterial RNA polymerase using time-resolved cryo-EM

Octavio Mondragon-Palomino, PhD California Institute of Technology In situ dissection of bacteria-bacteria interactions on the mucosa of the mammalian gut

Priya Moorjani, PhD Columbia University Learning about the rate and chronology of human evolution

Amy Elizabeth Shyer, PhD University of California-Berkeley Investigating mechano-chemical mechanisms of mesenchymal morphogenesis in skin and bone

Amy M. Weeks, PhD University of California-San Francisco Untangling the protease web: Chemical and enzymatic probes for dissection of proteolytic signaling in immune cells

2016

Ahmet F. Coskun, Ph.D. California Institute of Technology Computational single molecule imaging and barcoding: Exploring cellular identity at the single cell transcript level

Alexander G. Huth, Ph.D. University of California-Berkeley Comprehensive functional mapping of human cortex using generative models

Ashley Laughney Bakhoum, Ph.D. Sloan-Kettering Institute Uncovering transcriptional vulnerabilities in latent metastasis

Michael J. Mitchell, Ph.D. Massachusetts Institute of Technology High-throughput in vivo nucleic acid delivery screening via molecular barcoding of nanoparticles for bone marrow-related diseases

Arthur Prindle, Ph.D. University of California-San Diego Electrical signaling and multicellular organization

Adrianne Marie Rosales, Ph.D. University of Colorado-Boulder Dynamic viscoelastic hydrogels to study mechanisms of fibrosis

David M. Schneider, Ph.D. Duke University Neural circuits for making predictions and learning from mistakes

Amy Wesolowski, Ph.D. Princeton University Impact of human travel on infectious disease dynamics

Jing Yan, Ph.D. Princeton University Resolving and analyzing living bacterial biofilms at the single cell level

Weijian Yang, Ph.D. Columbia University Holographic mapping and manipulation of neuronal microcircuits

2014

Ariana E Anderson, Ph.D. University of California-Los Angeles It's all in your head: isolating the placebo effect in the brain to reduce drug development costs

Amit Choudhary, Ph.D. Harvard University / Broad Institute Snakes, antioxidants, and diabetes

Matthew C Good, Ph.D. University of California-Berkeley Cell size and shape dependence of intracellular assembly and signaling

Prashant Mali, Ph.D. Harvard Medical School Engineering normal and diseased liver organogenesis

Nikhil S Malvankar, Ph.D. University of Massachusetts-Amherst Direct visualization of charge flow in individual native biomolecules

Elizabeth A Nance, Ph.D. Johns Hopkins University Nanoparticle-mediated targeted therapies for pediatric brain disorders

Elizabeth Hesper Rego, Ph.D. Harvard School of Public Health Drug use on the single cell level: differential antibiotic susceptibility of mycobacterial cells using fluorescent reporters.

Ramkumar Sabesan, Ph.D. University of California-Berkeley School of Optometry Studying visual function on a cellular scale

Kimberly Murley Stroka, Ph.D. Johns Hopkins University School of Medicine Engineering blood-brain barrier mechanobiology in tumor metastasis

Michael D. Vahey, Ph.D. University of California-Berkeley School of Public Health Uncovering the dynamics of enveloped virus assembly

Heng Xu, Ph.D. Baylor College of Medicine Deciphering stochastic transcriptional regulation at the single-event level

Xin Zhang, Ph.D. Scripps Research Institute Scrutinizing the cellular and molecular mechanisms that create and maintain the functional proteome using chemical probes

2013

Gregory R. Bowman, Ph.D. University of California - Berkeley Decrypting cryptic allosteric sites resulting from protein flexibility

Yaniv Erlich, Ph.D. Whitehead Institute for Biomedical Research Dissecting complex phenotypes using web 2.0 social networks

Stephanie I. Fraley, Ph.D. Johns Hopkins University School of Medicine Digitizing microRNA: integrated profiling and discovery for rapid, quantitative, and broad-scale detection in infectious disease

Hernan G. Garcia, Ph.D. Princeton University Wiring up the synthetic fly

Karen E. Kasza, Ph.D. Memorial Sloan-Kettering Cancer Center Mechanical cues coordinating cell behaviors during morphogenesis

Gabriel Kwong, Ph.D. Massachusetts Institute of Technology Nanoparticles that amplify biomarkers in vivo for ultrasensitive metastasis monitoring

Megan N. McClean, Ph.D. Princeton University Optogenetic and microfluidic tools for generating dynamic inputs to interrogate and control biological networks

Mikhail G. Shapiro, Ph.D. University of California - Berkeley Genetically encoded reporters for sensitive non-invasive imaging of biological function

Paul A. Sigala, Ph.D. Washington University Mechanistic probes of heme metabolism in malaria parasites

Bo Wang, Ph.D. University of Illinois-Urbana-Champaign In vivo imaging and functional genomic analysis of stem cells in human parasitic worm schistosoma

2012

Buz M. Barstow, Ph.D. Harvard Medical School Evolving the limits of metabolism and in vivo catalysis

ShiNung Ching, Ph.D. Harvard Medical School Towards treatments in disorders of consciousness and new models of general anesthesia

Kwanghun Chung, Ph.D. Stanford University Clear, Lipid-exchanged, Anatomically Rigid, Imaging/immunostaining-compatible, Tissue hYdrogel (CLARITY) technology for high-throughput and high-content whole tissue analysis

Robert Gregg, Ph.D. Northwestern University From machine to biomimetic control in robot-assisted walking

Maureen E. Hillenmeyer, Ph.D. Stanford University In vivo synthetic evolution of bioactive natural products

Allon Moshe Klein, Ph.D. Harvard Medical School Defining patterns and mechanisms of stem cell fate choice

Sergey A. Kryazhimskiy, Ph.D. Harvard University Predicting evolution in microbial populations

Heather J. Kulik, Ph.D. Stanford University Deciphering the role of the protein scaffold in enzyme catalysis with fast and accurate computation

Lulu Qian, Ph.D. California Institute of Technology Exploring and re-realizing the principles of information processing in biology using artificial nucleic-acid systems

Jesse G. Zalatan, Ph.D. University of California - San Francisco Entropic contributions to efficiency in biochemical networks

Danielle (Dani) S. Bassett, PhD
Peter Skirkanich Professor at the University of Pennsylvania
External Professor of the Santa Fe Institute
Department of Bioengineering
University of Pennsylvania

 

Carlos Brody, PhD
Wilbur H. Gantz III ’59 Professor of Neuroscience
Investigator, Howard Hughes Medical Institute
Princeton University

 

Hana El-Samad, PhD
Senior Vice President and Director, Institute of Computation, Altos Labs
Professor, Department of Biochemistry and Biophysics
University of California, San Francisco

 

Polly Fordyce, PhD
Associate Professor
Bioengineering and Genetics
Stanford University

 

Daniel A. Hammer, PhD
Alfred G. and Meta A. Ennis Professor of Bioengineering
Director, Penn Center for Precision Engineering for Health
Department of Bioengineering
University of Pennsylvania

 

Princess Imoukhuede, PhD
Hunter and Dorothy Simpson Professor and Chair
School of Medicine & College of Engineering
University of Washington

 

Melissa Kemp, PhD
Carol Ann & David D. Flanagan Endowed Chair and Professor
Department of Biomedical Engineering
Georgia Institute of Technology & Emory University

 

Anshul Kundaje, PhD
Associate Professor
Departments of Genetics and Computer Science
Stanford University

 

Christina Leslie, PhD
Professor, Weill Cornell Medicine
Member, Computational and Systems Biology Program
Memorial Sloan Kettering Cancer Center

 

Stephanie Palmer, DPhil
Associate Professor
Department of Organismal Biology and Anatomy
Department of Physics
The University of Chicago

 

Liam Paninski, PhD
Professor, Departments of Statistics and Neuroscience
Columbia University

 

David Schneider, PhD
Associate Professor
Center for Neural Science
New York University

 

Georg Seelig, PhD
Chris and Heidi Stolte Professor
Paul G. Allen School of Computer Science & Engineering
Department of Computer & Electrical Engineering
University of Washington

 

Melissa Skala, PhD
Carol Skornicka Chair, Morgridge Institute for Research
Professor of Biomedical Engineering
University of Wisconsin–Madison

 

Kandice Tanner, PhD
Senior Investigator
Laboratory of Cell Biology
National Cancer Institute

 

Matt Thomson, PhD
Assistant Professor of Computational Biology
California Institute of Technology

 

Shyni Varghese, PhD (Co-Chair)
Professor of Biomedical Engineering, Mechanical Engineering & Materials Science, and Orthopedic Surgery
Pratt School of Engineering
Duke University

 

Corey Wilson, PhD
Love Family Endowed Professor
Professor of Engineering
School of Chemical & Biomolecular Engineering
Georgia Institute of Technology

 

Jesse Zalatan, PhD (Co-Chair)
Associate Professor, Department of Chemistry
University of Washington

 

Additional members may be added to the committee.

Award Timeline

Sep 02, 2025

Letter of Intent Deadline

Nov 24, 2025

Invites for full proposal

Jan 12, 2026

Application Deadline

Apr 21 - 22, 2026

Interviews

Jun 01, 2026

Notice of Award

Jul 01, 2026

Award Start Date

Jun 30, 2031

Award End Date

Program Contacts

Tammy Collins, PhD

Program Officer

919-991-5120

Eliza Gary

Program Associate

919-991-5107

Lama Haidar

Program Coordinator

919-991-5115