Investigators in the Pathogenesis of Infectious Disease

Application Deadline:

Nov 14, 2024





Now Accepting Applications

Eligibility & Application Process:

The competition will employ a two-stage process.

Request for Proposals

Grant Recipients


Kimberly Davis, PhD Johns Hopkins Bloomberg School of Public Health Utilizing a 3D human abscess model to uncover antibiotic persistence mechanisms

Tera Levin, PhD University of Pittsburgh How mechanisms of pathogenesis arise from environmental battlegrounds

Monica Mugnier, PhD Johns Hopkins Bloomberg School of Public Health Role of extravascular spaces in Trypanosoma brucei antigenic variation

Teresa O’Meara, PhD University of Michigan Discovery and functional analysis of novel virulence factors in Candida auris

Lena Pernas, PhD David Geffen School of Medicine at University of California-Los Angeles Organellar sensing of microbes

Jeremy Rock, PhD Rockefeller University Host-pathogen interactions that drive Mycobacterium tuberculosis persistence in caseum

Christoph Thaiss, PhD University of Pennsylvania, Perelman School of Medicine Gut-brain communication in enteric infection

Aaron Whiteley, PhD University of Colorado Boulder From humans to bacteria, how do cells resist viral infections?


Mariana Byndloss, DVM., PhD Vanderbilt University Role of diet-microbiota interactions during Salmonella gastroenteritis

Yi-Wei Chang, PhD University of Pennsylvania Uncovering in situ structural mechanisms of key activities driving apicomplexan parasites’ invasion into human cells for their infection

Tamia Harris-Tryon, MD, PhD University of Texas Southwestern Medical Center-DallasDetermining the Impact of Androgens on Staphylococcus aureus Pathogenesis

Maayan Levy, PhD University of PennsylvaniaTuft cell-neuron interactions in helminth infection

Shruti Naik, PhD New York University School of MedicineDecoding mechanisms of infection-associated tissue repair

Andrea Reboldi, PhD University of Massachusetts Medical SchoolRegulation of intestinal humoral immunity by cholesterol metabolites

Marta Rodriguez-Garcia, MD. PhDTufts UniversityInnate lymphoid cell control of mucosal HIV infection

Jing Yan, PhDYale UniversityDeciphering Molecular Mechanism Underlying Biofilm Adhesion


Jonathan Abraham, MD, PhD Harvard Medical School Molecular evolution of viral receptor-binding domains

Salvador Almagro-Moreno, PhD University of Central Florida Disentangling pathoadaptations in emergent pathogens: The Vibrio vulnificus paradigm

Sophie Helaine, PhD Harvard Medical School Dynamics and role of DNA accumulation in Salmonella persisters during infection

Steven Josefowicz, PhD Weill Medical College of Cornell University Epigenetic regulation of immunity: molecular mechanisms of inflammatory priming and altered hematopoiesis

Christopher LaRock, PhD Emory University School of Medicine Keratinocyte pyroptosis guards against invasive bacteria

Vineet Menachery, PhD University of Texas Medical Branch The Role of Glycosylation in Coronavirus Spreading Events

Michael Reese, PhD University of Texas Southwestern Medical Center – Dallas Mechanisms of self-assembly and dynamics of the Apicomplexan apical invasion & secretion machinery

Rebecca Voorhees, PhD California Institute of Technology Novel host factors for viral membrane protein biogenesis

Taia Wang, MD, PhD Stanford University Biology of afucosylated SARS-CoV-2 IgGs

Emily Wong, MD University of Alabama-Birmingham Interactions between the human host and M.tb during subclinical tuberculosis


Lawrence A David, PhD Duke University Dietary strategies for enhancing bacterial pathogen resistance in the gut

Matthew D Daugherty, PhD University of California-San Diego Finding the pressure points: Evolution-guided discovery of novel host-virus conflicts

Elizabeth S Egan, MD, PhD Stanford University School of Medicine Dissecting host-parasite interactions between Plasmodium falciparum and the bone marrow

Gianna E Hammer, PhD Duke University Decoding T cell mediated mechanisms underpinning sterilizing immunity without adverse pathology at mucosal barriers

Timothy W Hand, PhD University of Pittsburgh Mechanisms of tissue resident memory T cell protection against enteric infection

Nicholas S Heaton, PhD Duke University School of Medicine Hormone mediated regulation of antiviral immune responses

Laura-Isobel McCall, PhD

University of Oklahoma Role of spatial metabolic heterogeneity in disease tropism

Helen M Lazear, PhD University of North Carolina-Chapel Hill Host Range Determinants of Emerging Flaviviruses

Sebastian Lourido, PhD Massachusetts Institute of Technology Mapping pathogen coevolution through host diversity

Jakob von Moltke, PhD University of Washington School of Medicine Establishment, maintenance, and antigen specificity of T cell memory in helminth infection

John Whitney, PhD McMaster University Role of adenosine-containing alarmones in commensal and pathogenic bacteria


Megan T Baldridge, MD, PhD Washington University School of Medicine Unbiased identification of novel antiviral effectors against enteric viral pathogens using CRISPR screening

Brian P Conlon, PhD University of North Carolina-Chapel Hill Antibiotic tolerance induced by the innate immune response

Gretchen Diehl, PhD Memorial Sloan Kettering Cancer Center The microbiota sets the stage for proper immunity to intestinal pathogens

Asma I Hatoum, PhD University of Illinois, Urbana-Champaign Characterizing the antiviral secretome of pathogenic staphylococci

Iliyan D Iliev, PhD Weill Medical College of Cornell University Gastrointestinal Fungal Infections: What Should The Immune System Watch For?

Philip J Kranzusch, PhD Harvard Medical School Mechanism of CD-NTase signaling in bacterial pathogenesis and host-microbe interactions

Anna Marie Selmecki, PhD University of Minnesota Medical School Genome Plasticity in Fungal Adaptation and Pathogenesis

Golnaz Vahedi, PhD University of Pennsylvania Deciphering how lentiviruses hijack the 3D genome architecture of host cells

Ivan Zanoni, PhD Harvard Medical School Type III interferons at the crossroads between tissue tolerance and immune resistance in lung superinfections


Theresa Alenghat, DVM., PhD University of Cincinnati Dietary regulation of innate intestinal immunity

Francis Alonzo, PhD Loyola University-Chicago Deciphering how bacterial pathogens evade innate immunity

Isaac M. Chiu, PhD Harvard Medical School Neuronal regulation of influenza virus infection

Jun R. Huh, PhD Harvard Medical School Maternal gut bacteria, viral infection and neurodevelopmental disorder

Ivaylo Ivanov, PhD Columbia University Regulation of mucosal infections by innate lymphoid cells

Leigh Knodler, PhD Washington State University Remain confined or break free? Intracellular niche selection by Gram-negative bacteria

Kristin N. Parent, PhD Michigan State University Enter the goliaths: structure and function of giant virus entry mechanisms

John W. Schoggins, PhD University of Texas Southwestern Medical Center-Dallas Genetic dissection of innate immune pathways that modulate viral infection

Kimberley D. Seed, PhD University of California - Berkeley The impact of fluctuating microenvironments on phage-bacteria interactions in the human intestinal tract

Randy Stockbridge, PhD University of Michigan-Ann Arbor The molecular physiology of long-range electrical communication in bacterial biofilms

Ellen Yeh, MD, PhD Stanford University Targeting an ancient endosymbiosis in modern-day parasites


Jan E. Carette, Ph.D. Stanford University Hunting host factors critical for viral infection

James J. Collins, Ph.D. University of Texas Southwestern Medical Center-Dallas Defining regulators of schistosome reproductive development

Jorge Henao-Mejia, M.D., Ph.D. University of Pennsylvania Perelman School of Medicine Regulation of white adipose tissue by the microbiota

Ivan Marazzi, Ph.D. Icahn School of Medicine at Mount Sinai Role of nuclear granules in viral pathogenesis

John-Demian Sauer, Ph.D. University of Wisconsin-Madison The war within: identification and characterization of antibacterial cell instrinsic defenses in the host cell cytosol

Aimee Shen, Ph.D. Tufts University School of Medicine Role of a conserved DNA methyltransferase during Clostridium difficile infection

Michael Shiloh, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas Effect of mycobacterial lipid mediators on nociceptive neurons and cough induction

Gregory F. Sonnenberg, Ph.D. Weill Medical College of Cornell University Innate immune regulation of host-microbe interaction

Peter J. Turnbaugh, Ph.D. University of California-San Francisco Koch's postulates revisited: microbiome editing to prove the microbial etiology of human disease

David Veesler, Ph.D. University of Washington Characterization of the mechanisms of Nipah virus entry into host cells and humoral immune response

Gabriel D. Victora, Ph.D. Rockefeller University How prior antigenic exposure constrains the response to influenza vaccination

Sebastian E. Winter, Ph.D. University of Texas Southwestern Medical Center-Dallas Metabolic host-microbe interactions in the intestinal tract


Catherine Blish, MD, PhD Stanford University Training natural killer cells to fight HIV

Caroline Buckee, PhD Harvard School of Public Health The impact of human red blood cell heterogeneities and dynamics on malaria parasite virulence

Jason M. Crawford, PhD Yale University A functional metagenomic screen to systematically identify human-bacteria interactions

Elizabeth A. Grice, PhD  University of Pennsylvania Skin microbiome functions in colonization resistance to pathogens

Stacy M. Horner, PhD Duke University Medical Center Regulation of antiviral host response by RNA modifications

Adam S. Lauring, MD, PhD  University of Michigan-Ann Arbor The evolution of pathogen virulence and transmissibility

Andrew Mehle, Ph.D. University of Wisconsin Defining the functional landscape between intracellular pathogens and the host

Marion Pepper, PhD  University of Washington The development and function of Plasmodium-specific memory B cells

June Round, PhD  University of Utah Influence of the microbiota on neuro-inflammation

Mohammad R. Seyedsayamdost, PhD  Princeton University Deciphering the small molecule vocabulary of human microbiome Streptococci

Christina Stallings, PhD  Washington University Consequences of neutrophil-mycobacteria interactions

Harris Wang, Ph.D. Columbia University Mapping host-microbe and inter-microbial networks at ultra-high spatial resolution


Jörn Coers, D.Phil., Ph.D. Duke University Host-mediated lysis of cytoplasmic pathogens

Min Dong, Ph.D. Harvard Medical School Host factors conferring susceptibility to Clostridium difficile toxins

Christine M. Dunham, Ph.D. Emory University School of Medicine Characterization of pathways involved in bacterial persistence and antibiotic resistence

Nels C. Elde, Ph.D. University of Utah A new class of retrogenes modulating pathogenesis

Scott E. Hensley, Ph.D. University of Pennsylvania Effect of maternal antibodies on the neonatal immune response to influenza virus

Audrey R. Odom, M.D., Ph.D. Washington University Insights into the chemical ecology of malaria parasites

Alexander Ploss, Ph.D. Princeton University Breaking species barriers of human hepatotropic pathogens

Amariliz Rivera, Ph.D. Rutgers University-Rutgers Biomedical and Health Sciences-New Jersey Medical School Mechanisms of bidirectional innate cell licensing in antifungal immunity

Sunny Shin, Ph.D. University of Pennsylvania Perelman School of Medicine Overcoming pathogen-mediated translation inhibition to enable robust immune defense

Joseph C. Sun, Ph.D. Memorial Sloan-Kettering Cancer Center Natural killer cell control of cytomegalovirus infection


Jesse D. Bloom, Ph.D. University of Washington Understanding the stochasticity of viral infection at the level of single cells

Igor E. Brodsky, Ph.D. University of Pennsylvania The role of chemokine-chemokine receptor interactions in anti-bacterial protective immunity

Ken Cadwell, Ph.D. New York University School of Medicine Gene-microbe interactions in inflammatory bowel disease

Matthew James Evans, Ph.D. Icahn School of Medicine at Mount Sinai Determinants of hepatitis C virus persistence

Andrew L. Goodman, Ph.D. Yale University Understanding pathogen-commensal interaction in the earliest stages of infection

Elissa A. Hallem, Ph.D. University of California-Los Angeles Deciphering the interactions between skin-penetrating nematodes and bacteria

Sun Hur, Ph.D. Harvard Medical School Mechanism for dsRNA-dependent and -independent activation of the antiviral gene, PKR

Rahul Manu Kohli, M.D., Ph.D. University of Pennsylvania Tuning evolution and antibiotic resistance by modulating the SOS pathway

Li-Jun Ma, Ph.D. University of Massachusetts-Amherst Supernumerary chromosomes and pathogenicity of opportunistic fungal infections

Luciano A. Marraffini, Ph.D. Rockefeller University Effect of type III CRISPR-Cas immunity on phage-mediated staphylococcal pathogenesis

Daniel Mucida, Ph.D. Rockefeller University Adaptation of immune cells to the gut tissue: consequences for immunity and tolerance

Nan Yan, D. Phil. University of Texas Southwestern Medical Center-Dallas Innate immune sensing and pathogenesis of cytosolic bacteria


Robert A. Cramer, Ph.D. Dartmouth College Bioenergetics and microbial pathogenesis sufficiency

Michael A.  Fischbach, Ph.D. University of California-San Francisco Novel microbiota-derived molecules that modulate the host immune response

De'Broski R. Herbert, Ph.D. University of California-San Francisco Trefoil factor proteins modulate host immunity against hookworms

Tobias M. Hohl, M.D., Ph.D. Memorial Sloan-Kettering Cancer Center Tracing innate control over respiratory and systemic fungal infection

Alexei V. Korennykh, Ph.D. Princeton University Systems analysis of pathogen defense mediated by 2', 5'-linked isoRNA

Matthias Marti, Ph.D. Harvard University Cellular communication in malaria parasites

Erika L. Pearce, D.Phil., Ph.D. Washington University Cellular metabolism in immunity to infection

Manuela Raffatellu, M.D. University of California-Irvine Characterization of novel populations of neutrophils during bacterial infection

Daniel B. Stetson, Ph.D. University of Washington Why do DNA viruses cause cancer?

Niraj H. Tolia, Ph.D. Washington University School of Medicine Molecular basis for and inhibition of red blood cell invasion by Plasmodium parasites

Victor J. Torres, Ph.D. New York University School of Medicine Staphylococcus aureus pore-forming toxins: leukocyte killing and beyond

Robert T.  Wheeler, Ph.D. University of Maine Phagocytes block fungal dimorphism to defend the epithelial barrier


Abraham Brass, M.D., Ph.D. University of Massachusetts Medical School Defining dengue virus’s dependencies: discovery and characterization of host factors required for viral replication

Dustin Brisson, Ph.D. University of Pennsylvania Evolution of original antigenic sin in Lyme disease

Michael Federle, Ph.D. University of Illinois-Chicago Interspecies communication among commensal and pathogenic bacteria

Xiarong Lin, Ph.D. Texas A&M University Fungal communication and pathogenicity

Suzanne Noble, M.D., Ph.D. University of California-San Francisco Discovery of a cell type switch that drives fungal-mammalian commensalism

Sara Sawyer, Ph.D. University of Texas-Austin Genetics of viral species tropism

Emily Troemel, Ph.D. University of California-San Diego Microsporidia virulence factors exploit host cell physiology

David Weiss, Ph.D. Emory University Novel RNAi-like system controls bacterial innate immune evasion and virulence

Felix Yarovinsky, M.D. University of Texas Southwestern Medical Center TLR-independent host resistance to protozoan parasites

Liang Zhou, M.D., Ph.D. Northwestern University Environmental impact on host-pathogen interaction


Neal M. Alto, Ph.D. University of Texas Southwestern Medical Center Systems architecture of bacterial effector/host membrane interactions

Anna I. Bakardjiev, M.D. University of California-San Francisco School of Medicine Pregnancy-related pathogenicity determinants of Listeria monocytogenes

Juliane Bubeck Wardenburg, M.D., Ph.D. University of Chicago Tuning of the host-bacterial interaction by a pore-forming toxin

Carolyn B. Coyne, Ph.D. University of Pittsburgh School of Medicine Actin cytoskeleton and antiviral innate immune signaling

Sarah M. Fortune, M.D. Harvard University Quick change: polarity, diversity and virulence in Mycobacterium tuberculosis

Chyi-Song Hsieh, M.D., Ph.D. Washington University School of Medicine Host discrimination between pathogenic and commensal bacteria in the colon

Jonathan C. Kagan, Ph.D. Harvard Medical School Novel approaches to study RIG-I like receptor mediated antiviral immunity

Julie K. Pfeiffer, Ph.D. University of Texas Southwestern Medical Center How gut microbes enhance enteric virus infectivity

Christopher S. Sullivan, Ph.D. University of Texas-Austin Herpes virus immune evasion via non-coding RNA regulatory elements

Sing Sing Way, M.D., Ph.D. University of Minnesota Medical School Maternal regulatory T cells control the immune pathogenesis of prenatal infection


David M. Aronoff, M.D. University of Michigan-Ann Arbor Prostaglandin E2 synthesis and signaling in the pathogenesis of puerperal Group A Streptococcus infections

Gregory M. Barton, Ph.D. University of California-Berkeley Interactions between TLRs and intracellular pathogens

Julie Magarian Blander, Ph.D. Mount Sinai School of Medicine Innate immune recognition of vita-PAMPs: a new class of pathogen associated molecular patterns that signifies microbial viability

Sara R. Cherry, Ph.D. University of Pennsylvania Systems biology of Alphavirus infection

Jonathan Dworkin, Ph.D. Columbia University Characterization of a novel family of receptors mediating metazoan recognition of microbes

Ekaterina Heldwein, Ph.D. Tufts University School of Medicine Structural mechanism of herpes virus egress

Sarkis K. Mazmanian, Ph.D. California Institute of Technology Novel probiotic therapy for microbial infections

Joseph D. Mougous, Ph.D. University of Washington Breaching the commensal barrier to infection with type VI secretion

Justin L. Sonnenburg, Ph.D. Stanford University School of Medicine Mechanisms of intestinal microbiota-conferred protection from enteric pathogen

Benjamin R. tenOever, Ph.D. Mount Sinai School of Medicine Small RNA-mediated control of microbes


Jen-Tsan Ashley Chi, M.D., Ph.D. Duke University Medical Center Sequence determinant of the Plasmodium falciparum gene regulation by human microRNAs

K. Heran Darwin, Ph.D. New York University School of Medicine Ubiquitin-like proteins in bacterial pathogens

Denise Monack, Ph.D. Stanford University Host-pathogen interactions during persistent Salmonella infection

Maya Saleh, Ph.D. McGill University Regulation and molecular mechanisms of NLR-mediated innate immunity

Erica O. Saphire, Ph.D. Scripps Research Institute Arenavirus GP: architecture, receptor binding sites, and immune recognition

Russell Vance, Ph.D. University of California-Berkeley Innate immune cytosolic immunosurveillance pathways for sensing bacterial pathogens


David Artis, Ph.D. University of Pennsylvania Tracking helminth-specific immune responses in vivo

Richard Bennett, Ph.D. Brown University Phenotypic variation and host adaptation by the human fungal pathogen Candida albicans

Miriam Braunstein, Ph.D. University of North Carolina-Chapel Hill Identification of in vivo-secreted proteins of Mycobacterium tuberculosis with roles in host-pathogen interactions

James Carlyle, Ph.D. University of Toronto MHC-independent recognition of infected cells by natural killer cells of the innate immune system

Stephen Girardin, Ph.D. University of Toronto The Nod-like receptor Nod9 links mitochondrial dynamics and innate immunity to bacterial pathogens

Chuan He, Ph.D. University of Chicago How Staphylococcus aureus senses host immune defenses

Kent L. Hill, Ph.D. University of California-Los Angeles Cell-cell communication and social motility in pathogenesis and development of African trypanosomes

D. Borden Lacy, Ph.D. Vanderbilt University Medical Center Structural mechanisms of Heliobacter pylori pathogenesis

John MacMicking, Ph.D.

PERSON Yale University School of Medicine Immune control of human phagosomal pathogens by a novel GTPase superfamily

Adrie J.C. Steyn, Ph.D. University of Alabama-Birmingham Carbon monoxide and Mycobacterium tuberculosis persistence

Timothy L. Tellinghuisen, Ph.D. The Scripps Research Institute Subversion of a host kinase and vesicle trafficking components for the production of infectious hepatitis C virus

David Wang, Ph.D. Washington University School of Medicine A genomics-based approach to novel viral etiologies of diarrhea

Marvin Whiteley, Ph.D. University of Texas-Austin Mechanistic insight into host modulation of bacterial group activities

Dong Yu, Ph.D. Washington University School of Medicine Modulation of the DNA damage response by human cytomegalovirus


Benjamin K. Chen, M.D., Ph.D. Mount Sinai School of Medicine Dissemination of HIV through virological synapses

Andrew Darwin, Ph.D. New York University School of Medicine Mechanisms of Pseudomonas aeruginosa tolerance to secretin-induced stress during host infection

Michael R. Farzan, Ph.D. Harvard Medical School Parallel identification of obligate viral receptors

Britt Glaunsinger, Ph.D. University of California-Berkeley Global modulation of cellular gene expression by an oncogenic human herpesvirus

Karen J. Guillemin, Ph.D. University of Oregon Regulation of gut epithelial cell homeostasis by the microbiota

Lora V. Hooper, Ph.D. University of Texas Southwestern Medical Center Innate immune responses to commensal bacteria at gut epithelial surfaces

Eckhard Jankowsky, Ph.D. Case Western Reserve University Molecular mechanisms of pathogen identification by the pattern recognition receptors RIG-I and MDA5

Barbara I. Kazmierczak, M.D., Ph.D. Yale University The role of injury in Pseudomonas aeruginosa pulmonary infection

Manuel Llinas, Ph.D. Princeton University Global analysis of the Plasmodium falciparum metabolome

Harmit S. Malik, Ph.D. University of Washington Evolution-based identification and functional study of intracellular host-virus interactions

Dorian B. McGavern, Ph.D. The Scripps Research Institute Chemical and molecular approaches to probe viral pathogenesis in real time

Yorgo Modis, Ph.D. Yale University Cell entry and innate immune recognition of flaviviruses

Neal Silverman, Ph.D. University of Massachusetts Medical School Intracellular bacterial recognition in the Drosophila innate immune respons

Raphael H. Valdivia, Ph.D. Duke University Medical Center The role of secreted bacterial proteases in chlamydial pathogenesis

Andres Vazquez-Torres, D.V.M., Ph.D. University of Colorado-Denver and Health Sciences Center-Fitzsimons Campus Effects of nitrosative stress on bacterial two component regulatory systems in innate host defense

Ning Zheng, Ph.D. University of Washington Viral hijacking of host ubiquitin ligase machinery


Choukri Ben Mamoun, Ph.D. University of Connecticut Health Center Function and regulation of host and parasite nutrient transporters during malaria infection

Helen E. Blackwell, Ph.D. University of Wisconsin-Madison Interception of bacterial quorum sensing with synthetic ligands

Blossom Damania, Ph.D. University of North Carolina-Chapel Hill Role of viral signaling proteins in the pathogenesis of Kaposi's sarcoma-associated herpes virus (KSHV)

Manoj T Duraisingh, Ph.D. Harvard School of Public Health Epigenetic control of virulence gene expression in Plasmodium falciparum

Peter J. Espenshade, Ph.D. Johns Hopkins University School of Medicine Oxygen-sensing and adaptation to host tissue hypoxia in the human fungal pathogen Cryptococcus neoformans

Robert F. Kalejta, Ph.D. University of Wisconsin-Madison Cellular and viral determinants of human cytomegalovirus lytic and latent replication cycles

Christian Munz, Ph.D. Rockefeller University Regulation of macroautophagy by viral infection

Kim Orth, Ph.D. University of Texas Southwestern Medical Center VopL, a Vibrio effector that nucleates actin

Ana Rodriguez, Ph.D. New York University School of Medicine The role of hypoxanthine degradation in malaria-induced pathogenesis

Karla Fullner Satchell, Ph.D. Northwestern University A mouse model for the role of toxins in cholera pathogenesis

Luis M Schang, D.V.M., Ph.D. University of Alberta Silencing and antisilencing in the regulation of viral gene expression

Eric Skaar, Ph.D. Vanderbilt University Medical Center In vivo identification of Staphylococcus aureus proteins that defend against host neutrophils

Vanessa Sperandio, Ph.D. University of Texas Southwestern Medical Center Interkingdom signaling in bacterial pathogenesis

Billy Tsai, Ph.D. University of Michigan Medical School How cholera toxin hijacks cellar machineries to transport across the ER membrane


Jody L. Baron, M.D., Ph.D. University of California-San Francisco School of Medicine Understanding immunopathogenesis of Hepatitis B virus

Matthew S. Bogyo, Ph.D. Stanford University School of Medicine Chemical mapping of proteolytic networks involved in Toxoplasma gondii pathogenesis

John H. Brumell, Ph.D. University of Toronto Recognition of bacteria in the cytosol of mammalian cells by protein conjugation systems

Tatjana Dragic, Ph.D. Albert Einstein College of Medicine of Yeshiva University Entry and intracellular trafficking of Hepatitis C virus

Michael S. Glickman, M.D. Memorial Sloan-Kettering Cancer Center Regulated intramembrane proteolysis in controlling Mycobacterium tuberculosis virulence and cell envelope composition

Akiko Iwasaki, Ph.D. Yale University Stromal cell contributions in innate and adaptive immune responses to mucosal viral infection

John S. Parker, B.V.M.S., Ph.D. Cornell University College of Veterinary Medicine Reovirus-induced apoptosis: the role of the viral outer-capsid protein mu1

Lalita Ramakrishnan, M.D., Ph.D. University of Washington School of Medicine Forward genetic screens in the zebrafish to identify host determinants of susceptibility to tuberculosis

Gregory A. Smith, Ph.D. Northwestern University Feinberg School of Medicine Coordination of herpes virus assembly and transport in axons of sensory neurons

Linda F. van Dyk, Ph.D. University of Colorado Health Sciences Center Analyzing tumor suppressors in the control of virus infection and inflammation

Sean P. Whelan, Ph.D. Harvard Medical School Exploration of the interaction of RNA viruses with their host cells


David C. Bloom, Ph.D. University of Florida College of Medicine Identification of neuron-specific factors that regulate HSV-1 chromatin structure and transcription during latency

Dana A. Davis, Ph.D.E University of Minnesota-Twin Cities Control of phenotypic switching and pathogenesis by the Mds3 protein

David A. Fidock, Ph.D. Albert Einstein College of Medicine of Yeshiva University Plasmodium falciparum transmembrane proteins and their role in parasite susceptibility to heme-binding antimalarials

Michael J. Gale, Jr. Ph.D. University of Texas Southwestern Medical Center Control of hepatitis C virus replication

Andrew S. Neish, M.D. Emory University School of Medicine Transgenic analysis of prokaryotic effector proteins in the eukaryote, Drosophila melanogaster

Eric J. Rubin, M.D., Ph.D. Harvard School of Public Health Cell signaling by bacterial cytokines in Mycobacterium tuberculosis

Wenqing Xu, Ph.D. University of Washington School of Medicine Innate immunity: how do Toll-like receptors recognize microbial pathogens?

Thomas C. Zahrt, Ph.D. Medical College of Wisconsin Mycobacterium tuberculosis regulators modulating reactivation


Barbara A. Burleigh, Ph.D. Harvard School of Public Health Functional characterization of the role of the host cell fibrogenic response in Trypanosoma cruzi infection

Zhijian J. Chen, Ph.D. University of Texas Southwestern Medical Center Roles of TRAF5-regulated IKK activators in innate immunity

Maurizio Del Poeta, M.D. Medical University of South Carolina-College of Medicine Roles for inositol phosphoryl ceramide synthase 1 (IPC1) in fungal-host interaction

Heidi Goodrich-Blair, Ph.D. University of Wisconsin-Madison Pathogenesis of Xenorhabdus nematophilus in insects: a model for the innate immune response to bacterial pathogens

David B. Haslam, M.D. Washington University-School of Medicine Mechanisms of Shiga toxin translocation and intoxication within host cells

Margarethe (Meta) J. Kuehn, Ph.D. Duke University Medical Center Toxin trafficking via vesicles

C. Erec Stebbins, Ph.D. Rockefeller University Structural studies of bacterial virulence factors

Ren Sun, Ph.D. University of California-Los Angeles-School of Medicine Identification of cellular factors that determine the fate of herpes virus infection: latency versus lytic replication

Chloe L. Thio, M.D. Johns Hopkins University School of Medicine The identification of human genes associated with hepatitis B virus outcomes

Award Timeline

Jul 18, 2024

Letter of Intent Deadline

Oct 04, 2024

Invitation to Submit a Full Proposal

Nov 14, 2024

Application Deadline

Apr 28 - 30, 2025

Finalist Interviews

May 31, 2025

Notice of Award

Jul 01, 2025

Award Start Date

Jun 30, 2030

Award End Date

Program Contacts

Victoria McGovern, Ph.D.

Senior Program Officer


Darcy Lewandowski

Program Associate

Kendi Kajogo

Program Coordinator