Next Gen Pregnancy Initiative

Application Deadline:

Dec 01, 2021

by

3:00pm

ET

Status:

Now Accepting Applications

Eligibility & Application Process:

For a full explanation of the eligibility requirements, view the Request for Proposals.

Request for Proposals

Grant Recipients

2021

Vikki M Abrahams, PhD Yale University Mechanisms regulating fetal membrane and neutrophil responses to infection

William Lee Kraus, PhD University of Texas Southwestern Medical Center-Dallas A Multi-Omics Approach to Understanding Human Placenta Gene Expression

Diana Monsivais, PhD Baylor College of Medicine Endometrial signaling pathways during peri-implementation as determinants of pregnancy success

Katy Patras, PhD Baylor College of Medicine Characterizing the role of the vaginal microbiota in group B Streptococcus colonization and dissemination

Joan T. Price, MD University of North Carolina-Chapel Hill Periconception evaluation of the vaginal microbiome and immune response to predict adverse birth outcomes in women with and without HIV

Mijo Simunovic, PhD Columbia University Dissecting the signaling and biomechanics of embryo implantation and failure using quantitative organoids of early human embryogenesis

Tamara Tilburgs, PhD University of Cincinnati The role of HLA-G+/C+ extra villous trophoblasts in placental inflammation

Yong Wang, PhD Washington University Noninvasive imaging of human myometrial microstructures and electrical contraction patterns during pregnancy

2019

Nima Aghaeepour, PhD Stanford University Multiomics Modeling of the Immunological Clock of Pregnancy

Adrian Erlebacher, MD, PhD University of California-San Francisco Epigenetic regulation of labor onset

Joanna Halkias, MD  University of California-San Francisco Harnessing immune regulatory mechanisms to target the fetal inflammatory response in preterm birth

Mala S. Mahendroo, PhD  University of Texas Southwestern Medical Center-Dallas Defining the Spatio-Temporal Drivers of Cervical Remodeling in Pregnancy and Parturition

Carole R. Mendelson, PhD  University of Texas Southwestern Medical Center-Dallas Fetal-Maternal Signaling in the Initiation of Labor

Aleksandar Stanic-Kostic, MD, PhD  University of Wisconsin-Madison Novel Innate Lymphoid Cells in Preterm Birth

2017

John Anthony Capra Ph.D. Vanderbilt University Integrating 'omics and electronic health records to elucidate the genetic architecture of preterm birth

Jonghwan Kim Ph.D. University of Texas-Austin Identifying genetic factors controlling normal and abnormal placental development

Tippi C. MacKenzie M.D. University of California-San Francisco A precision medicine approach to detect dysbiosis and immune activation in preterm birth

Kimani C. Toussaint Ph.D. University of Illinois-Urbana-Champaign Investigating the mechanobiology of cervical remodeling using a novel combination of optical microscopy and nanoindentation

Ge Zhang M.D., Ph.D. University of Cincinnati Genomic study of gestational length and preterm birth

2015

Senad Divanovic, Ph.D. University of Cincinnati Role of type I IFNs/IFNAR axis in inflammation-induced preterm birth

Laura Marie Ensign, Ph.D. Johns Hopkins University The role of vaginal progesterone delivery in cervical remodeling and preterm birth

John James Moore, M.D. Case Western Reserve University Determination of the Mechanisms of Preterm Premature Fetal Membrane Rupture Using a Novel in-vitro Model System

Mark Phillippe, M.D. Harvard Medical School Cell-free Fetal DNA - the Trigger for Spontaneous Parturition

Timothy York, Ph.D. Virginia Commonwealth University Epigenetic mechanisms of preterm birth in a racially mixed sample of pregnant women

2014

Trevor D. Burt, M.D. University of California-San Francisco Fetal immune activation and lineage switching in preterm labor

Kang Chen, Ph.D. Wayne State University The functions of B cells in pregnancy and the pathogenesis of preterm birth

David N. Cornfield, M.D. Stanford University School of Medicine Myometrial smooth muscle cell TRPV channel activity modulates contractility

Stephen Lye, Ph.D. University of Toronto Targeting leukocyte activation to prevent preterm labor

Vincent Joseph Lynch, Ph.D. University of Chicago Evolutionary forward genomic insights into the casual mechanisms of preterm birth

2013

George Scott Worthen, M.D. University of Pennsylvania Genetics of preterm birth

Francesco J. DeMayo, Ph.D. Baylor College of Medicine Progesterone receptor regulation of gravid myometrium

Amanda L. Lewis, Ph.D. Washington University Mucus barrier degradation in bacterial vaginosis-associated preterm birth

Claire Chougnet, Ph.D. University of Cincinnati Host-microbe cross-talk and pregnancy outcomes

Katharina Ribbeck, D.Phil., Ph.D. Massachusetts Institute of Technology Properties and functions of cervical mucus associated with preterm birth

2011

Kjersti M. Aagaard-Tillery, M.D., Ph.D. Baylor College of Medicine Contributions of maternal-fetal-mitochondrial genome and microbiome interactions to preterm birth

Julie Baker, Ph.D. Stanford University Genomic networks that guide trophoblast invasion and disease

Mala S. Mahendroo, Ph.D. University of Texas Southwestern Medical Center-Dallas Assessment of cervical ripening by sodium magnetic resonance imaging

Jeffrey C. Murray, M.D. University of Iowa Genomic signatures of gene expression and alternative splicing in preterm birth

Indira Mysorekar, Ph.D. Washington University Occult infections in the etiology of preterm birth

2009

Kjersti M. Aagaard-Tillery, M.D., Ph.D. Baylor College of Medicine Contributions of maternal-fetal-mitochondrial genome and microbiome interactions to preterm birth

Vikki M. Abrahams, Ph.D. Yale University The role of placental Nod-like receptors in infection-associated preterm labor

Julie Baker, Ph.D. Stanford University Genomic networks that guide trophoblast invasion and disease

Ronald W. Davis, Ph.D. Stanford University Unexplained Preterm birth

Michal Elovitz, M.D. University of Pennsylvania Targeting novel pathways in cervical remodeling for predicting prematurity: a combined biomarker and genomics approach

Michael Douglas House, M.D. Tufts Medical Center Beyond cervical length: development of a patient-specific model of cervical mechanical function in pregnancy pregnancy

Mala S. Mahendroo, Ph.D. University of Texas Southwestern Medical Center-Dallas Assessment of cervical ripening by sodium magnetic resonance imaging

Jeffrey C. Murray, M.D. University of Iowa Genomic signatures of gene expression and alternative splicing in preterm birth

Indira Mysorekar, Ph.D. Washington University Occult infections in the etiology of preterm birth

Carl P. Weiner, M.D., M.B.A. University of Kansas Initiator-effector gene sets regulating myometrial contractility during term and preterm labor

Award Timeline

Dec 01, 2021

Application Deadline

May 20, 2022

Notice of Award

Jun 01, 2022

Award Start Date

Mar 31, 2026

Award End Date

Program Contacts

Rolly Simpson

Senior Program Officer

919-991-5110

Kendra Tucker

Kendra Tucker

Program Associate

919-991-5115